Morphological Characteristics of Coronary and Carotid Atherosclerotic Plaques in Patients with Myocardial Infarction
Aim — to study the correlation between the thickness of the fibrous cap and collagen in the coronary and carotid plaques in patients with myocardial infarction.
Materials and methods. The objects of the study were 81 coronary and carotid atherosclerotic plaques obtained during autopsy study of 15 patients who died from complications of myocardial infarction. Histological and morphometric study and immunohistochemistry were performed. Immunohistochemical examination was carried out using monoclonal antibodies against collagen types II, III, IV, VI, VII.
Results. There is a combination of complicated, unstable and stable coronary and carotid atherosclerotic plaques in patients with myocardial infarction. Unstable atherosclerotic plaque is characterized by thinning of the fibrous cap mainly in the peripheral areas and the growth of destructive changes in the collagen types III, IV and VI.
Conclusion. There is a critical thinning in the caps of unstable carotid and coronary plaques in myocardial infarction with signs of disorganization of collagen, leading to decreased resistance to mechanical stress of this type of plaques.
1. Otsuka F, Yasuda S, Noguchi T, Ishibashi-Ueda H. Pathology of coronary atherosclerosis and thrombosis. Cardiovascular Diagnosis and Therapy. 2016;6(4):396-408. doi:10.21037/cdt.2016.06.01.
2. Narula J, Nakano M, Virmani R, et al. Histopathologic Characteristics of Atherosclerotic Coronary Disease and Implications of the Findings for the Invasive and Noninvasive Detection of Vulnerable Plaques. Journal of the American College of Cardiology. 2013; 61(10):1041-1051. doi:10.1016/j.jacc.2012.10.054.
3. Campbell IC, Weiss D, Suever JD, et al. Biomechanical modeling and morphology analysis indicates plaque rupture due to mechanical failure unlikely in atherosclerosis-prone mice. American Journal of Physiology — Heart and Circulatory Physiology. 2013; 304(3):H473-H486. doi:10.1152/ajpheart.00620.2012.
4. Ohayon J, Finet G, Le Floc’h S, et al. Biomechanics of Atherosclerotic Coronary Plaque: Site, Stability and In Vivo Elasticity Modeling. Annals of biomedical engineering. 2014;42(2):269-279. doi:10.1007/s10439-013-0888-1.
5. Koskinas KC, Sukhova GK, Baker AB, et al. Thin-Capped Atheromata with Reduced Collagen Content in Pigs Develop in Coronary Arterial Regions Exposed to Persistently Low Endothelial Shear Stress. Arteriosclerosis, thrombosis, and vascular biology. 2013;33(7):1494-1504. doi:10.1161/ATVBAHA.112.300827.
6. Seeger M, Karlas A, Soliman D, Pelisek J, Ntziachristos V. Multimodal optoacoustic and multiphoton microscopy of human carotid atheroma. Photoacoustics. 2016;4(3):102-111. doi:10.1016/j.pacs.2016.07.001.
7. Kong CH, Lin XY, Woo CC, et al. Characteristics of aortic wall extracellular matrix in patients with acute myocardial infarction: tissue microarray detection of collagen I, collagen III and elastin levels. Interactive Cardiovascular and Thoracic Surgery. 2013;16(1):11-15. doi:10.1093/icvts/ivs421.
8. Hansson GK, Libby P, Tabas I. Inflammation and plaque vulnerability. Journal of internal medicine. 2015;278(5):483-493. doi:10.1111/joim.12406.
Slatova LN, Fedorina TA, Bormotov AV, Samychin MYu, Buklesheva IM. Morphological Characteristics of Coronary and Carotid Atherosclerotic Plaques in Patients with Myocardial Infarction. Science & Innovations in Medicine. 2017;2(6):15-19.
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