The Use of Radiofrequency Thermal Ablation in Combine Treatment of Patients with Liver Bilobar Metastases from Colorectal Cancer

Аннотация

Aim — determination of RFTA place in the combined treatment of bilobar liver metastatic process of colorectal cancer.

Materials and methods. 176 patients with colorectal cancer with multiple (more than 4) bilobar liver metastases were included in the study after primary tumor removal. The research was held in Samara Regional Oncology Centre from 2001 to 2014. According to the treatment method patients were divided into two groups. Main group got the combined (chemotherapy + RFTA) treatment (98 patients). In control group only chemotherapy was applied to 78 patients.

Results. One-, two- and three-year OS were 73.5%, 25.1%, 7.2% in the main group and 39.6%, 6.3%, 2.1% in the control group. With RFTA application we reached the 1.8% index of four-year survival in the main group, while three-year survival in the control group was only 2.1%. The OS median reached 18 months in the main group and 11 months in the control group, OS curves in two comparing groups were significantly different( log-rank test 3.77, р=0,000).

Conclusion. Combination of RFTA with chemotherapy as the treatment of bilobar liver metastases of colorectal cancer, significantly improves the DFS and overall survival indexes, comparing to the group of patients who received only chemotherapy.

Список литературы

1.DavydovMI, Aksel' EM. StatistikazlokachestvennykhnovoobrazovaniivRossiiistranakhSNGv2009 g. VestnikGURONTsimBlokhinaRAMN.2011;Vol.22;3(85). Pril1. (InRuss.).

2. Minimal'nyeklinicheskierekomendatsiiEvropeiskogoObshchestvaMeditsinskoionkologii(ESMO). Izdatel'skaya gruppa RONTs im. N.N. Blokhina RAMN. M., 2009. (In Russ.).

3.Brouquet A, Benoist S, Nordlinger B. New Neoadjuvant Chemotherapy for Resectable Liver Metastases of Colorectal Cancer. Multidisciplinary Management of Liver Metastases in Colorectal Cancer. 2017; 169—175.

doi.org/10.1007/978-94-017-7755-1_12

4Gillams AR, Lees WR. Five-year survival in 309 patients with colorectal liver metastases treated with radiofrequency ablation. European Radiology. 2009;19:1206—13.

doi.org/10.1007/s00330-008-1258-5

5. Pozzo C, Barone C. Advances in neoadjuvant therapy for colorectalcancer liver metastases. Cancer Treatment Reviews. 2008;34:293—01.

doi.org/10.1016/j.ctrv.2008.01.004

6. Karim M. Eltawil, Nana Boame, Richard Mimeault et al. Patterns of recurrence following selective intraoperative radiofrequency ablation as an adjunct to hepatic resection for colorectal liver metastases. Journal of Surgical Oncology. 2014;110(6):734—738

doi.org/10.1002/jso.23689

7. Gleisner AL, Choti MA, Assumpcao L, Nathan H, Schulick RD, Pawlik TM. Colorectal liver metastases: recurrence and survival following hepatic resection, radiofrequency ablation, and combined resection-radiofrequency ablation. Arch Surg.2008;143(12):1204—1212.

doi:10.1001/archsurg.143.12.1204

8. Siperstein AE, Berber E, Ballem N et al. Survival after radiofrequency ablation of colorectal liver metastases: 10 year experience. Annals of Surgery. 2007;246:559—565

doi.org/10.1016/s0739-5930(08)79112-8

9. Pozzo C, Barone C. Advances in neoadjuvant therapy for colorectalcancer liver metastases. Cancer Treatment Reviews. 2008;34:293—01.

doi.org/10.1016/j.ctrv.2008.01.004

10. DolgushinBI, PatyutkoYuI, KosyrevVyu, SholokhovVN. Radiochastotnayatermoablatsiyaopukholeipecheni. M.: Prakticheskayameditsina, 2007. (In Russ.).

Для цитирования

Kaganov OI, Kozlov SV, Orlov AE, Blinov NV. The Use of Radiofrequency Thermal Ablation in Combine Treatment of Patients with Liver Bilobar Metastases from Colorectal CancerScience & Innovations in Medicine. 2018;2(10):4953.

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