Dynamics of Morphological Changes in Brachiocephalic Trunk Arteries Influenced of Atorvastatin Therapy in Patients of High Risk

Аннотация

Aim — to assess the morphological changes in the extracranial arteries of the brachiocephalic trunk in high-risk patients during atorvastatin therapy.

Materials and methods. The study included 78 patients with a high risk of death from cardiovascular disease (mean age 54.8 ± 4.4 years), according to SCORE ≥ 5% and <10%, with a moderately elevated level of OX (5.0-5.9 mmol/l) and LDL cholesterol (3.0-3.9 mmol/l) receiving atorvastatin at an initial dose of 40 mg/day.

Results. In the presented group of patients, atherosclerotic lesion was more often observed in the common carotid artery (CCA), equally expressed on both sides. On the background of therapy with atorvastatin, the greatest changes in terms of regression and stabilization of atherosclerotic plaques are noted in the CCA projection on the left. In 36 cases, during treatment, there is a decrease and stabilization of atherosclerotic plaques, in 2 cases —the thickness of the intima-media complex. In 14 patients regression of two previously visualized plaques was noted in the background of treatment, in 4 patients —regression of three plaques, in 4 patients —stabilization of two plaques.

Conclusions. Atorvastatin in the treatment of patients at high risk of death from cardiovascular disease contributes to the stabilization of carotid atherosclerosis and reduces the levels of atherogenic lipoproteins.

Conflicts of Interest: nothing to declare.

Список литературы

Scheen AJ.From atherosclerosis to atherothrombosis: from a silent chronic pathology to an acute critical event. Rev Med Liege.2018;73(5–6):224–228.

Olie RH, van der Meijden PEJ, Ten Cate H. The coagulation system in atherothrombosis: Implications for new therapeutic strategies. Res Pract Thromb Haemost. 2018;2(2):188–198. 

doi: 10.1002/rth2.12080

Mitchell C, Korcarz CE, Gepner AD et al. Ultrasound carotid plaque features, cardiovascular disease risk factors and events: The Multi-Ethnic Study of Atherosclerosis.Atherosclerosis. 2018 Jun 12. pii: S0021-9150(18)30312–5.

doi: 10.1016/j.atherosclerosis.2018.06.005 [Epub ahead of print]

Sargento-Freitas J,Pagola J, Rubiera Met al. Preferential effect of premorbid statinson atherothrombotic strokes through collateral circulation enhancement.EurNeurol.2012;68(3):171–6.

Rubanenko ОА. Correction of dyslipidemia in patients with coronary artery disease categories of high and very high risk of heart.Aspirantskiy vestnik Povolzhya..2009;3–4:65–68.(In Russ.).

Luo P, Wang L, Zhu H et al. Impact of Atorvastatin Combined with Ezetimibe for the Treatment of Carotid Atherosclerosis in Patients with Coronary Heart Disease. Acta Cardiol Sin.2016;32(5):578–585.

Wang J, Ai XB, Wang FZou YWet al.Efficacy of ezetimibe combined with atorvastatin in the treatment of carotid artery plaque in patients with type 2 diabetes mellitus complicated with coronary heart disease. IntAngiol. 2017;36(5):467–473.

doi: 10.23736/S0392-9590.17.03818-4

Lishchuk VA. Intellectual provision of diagnosis and treatment of circulatory disorders.Lekcii po serdechno-sosudistoj hirurgii. Pod red. L.A. Bokeriya. V 2-h t. T. 1. – M.: Izdatel'stvo NCSSKH im. A.N. Bakuleva RAMN, 2001. (In Russ.).

Nakagomi A, Shibui T, Kohashi K et al.Differential Effects of Atorvastatin and Pitavastatin on Inflammation, Insulin Resistance, and the Carotid Intima-Media Thickness in Patients with Dyslipidemia.J Atheroscler Thromb.2015;22(11):1158-71.

doi: 10.5551/jat.29520

Li Y, Gao S, An Y, Liu E, Zhao S. High dose atorvastatin therapy yields a better carotid atherosclerosis improvement in Chinese patients.IntJCardiol. 2015;185:131–2.

doi: 10.1016/j.ijcard.2015.03.126

Для цитирования

Rubanenko OA. Dynamics of Morphological Changes in Brachiocephalic Trunk Arteries Influenced of Atorvastatin Therapy in Patients of High RiskScience & Innovations in Medicine. 2018;3(11):3538.

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