Genotypes and Phenotypes of Alzheimer’s Disease

Аннотация

Aim – research of gene APOEfor definition of allele structures of the human population phenotypes resulting in risk of Alzheimer’s disease.

Materials and methods. Use of the Hardy—Weinberg theoryand statistical researches of the alleles distribution of gene APOEin a human population.

Results. Principles of the phenotype allelestructures formation resulting in risk of Alzheimer’s diseaseare investigated. The expediency of these phenotypes finding is shown. On the basis of the received phenotypes distribution in human population the dependence of phenotype frequencies on risk of Alzheimer’s diseaseis investigated. The most dangerous phenotypes are revealed.

Conclusion. On the basis of representation about dominant and recessive structure of gene APOE allelesit is shown that in a human population exists three phenotypes which determine the risk of Alzheimer’s disease. Distribution of these phenotypes in populations is investigated.

Conflicts of Interest: nothing to declare.

Список литературы

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Для цитирования

Volobuev AN, PyatinVF, Romanchuk NP, Aleksandrova NNGenotypes and Phenotypes of Alzheimer’s DiseaseScience & Innovations in Medicine. 2018;3(11):1720.

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