Morphometric Differential Diagnosis of Intestinal Tuberculosis and Crohn's Disease

Аннотация

Intestinal tuberculosis and Crohn’s disease are chronic granulomatous disorders that are difficult to differentiate histologically.

Aim — to describe the case of erroneous establishment of Crohn's disease in a patient with intestinal tuberculosis by the results of pathomorphological examination of biopsy specimens of the colon. The absence of anti-tuberculosis therapy led to the progression of the tuberculosis process with the development of tuberculosis of the larynx, lungs and ileum, followed by disability of the patient.

Conclusion. The given observation shows the necessity of introduction in the practice of clinical morphologist the morphometric methods of study of endoscopic biopsy specimens, allowing to differentiate between intestinal tuberculosis and Crohn's disease.

Conflicts of Interest: nothing to declare.

Список литературы

1. Du J, Ma Y-Y, Xiang H, Li Y-M. Confluent Granulomas and Ulcers Lined by Epithelioid Histiocytes: New Ideal Method for Differentiation of ITB and CD? A Meta Analysis. Green J, ed. PLoS ONE. 2014;9(10):e103303.

doi:10.1371/journal.pone.0103303

PMID: 25299041

2. Pulimood A, Ramakrishna B, Kurian G et al. Endoscopic mucosal biopsies are useful in distinguishing granulomatous colitis due to Crohn’s disease from tuberculosis. Gut. 1999;45(4):537–541. 

PMID: 10486361

3. Niriella MA, Kodisinghe SK, De Silva AP et al. Intestinal tuberculosis masquerading as difficult to treat Crohn disease: a case report. BMC Research Notes. 2016;9(1):417.

doi:10.1186/s13104-016-2222-0

PMID: 27557645

4. Limsrivilai J, Shreiner AB, Pongpaibul A et al. Meta-Analytic Bayesian Model For Differentiating Intestinal Tuberculosis from Crohn’s Disease. American journal of gastroenterology. 2017;112(3):415–427.

doi:10.1038/ajg.2016.529.

PMID: 28045023

5. Ye Z, Lin Y, Cao Q, He Y, Xue L. Granulomas as the Most Useful Histopathological Feature in Distinguishing between Crohn’s Disease and Intestinal Tuberculosis in Endoscopic Biopsy Specimens. Wall. P, ed. Medicine. 2015;94(49):e2157.

doi:10.1097/MD.0000000000002157

PMID: 26656343

6. Almadi MA, Ghosh S, Aljebreen AM. Differentiating intestinal tuberculosis from Crohn's disease: a diagnostic challenge. American journal of gastroenterology. 2009;104(4):1003–12.

doi: 10.1038/ajg.2008.162

PMID: 19240705

7. Kelly JH, Montgomery WW, Goodman ML, Mulvaney TJ. Upper airway obstruction associated with regional enteritis. Annals of otology, rhinology and laryngology. 1979;88(1Pt 1):95–99/

 doi:10.1177/000348947908800116

PMID: 426451

8. Park S, Park J, Kim HK, Kim JY, Hur SC, Lee JH, Jung JW, Lee J. Tracheal Involvement in Crohn Disease: the First Case in Korea. Clinical Endoscopy. 2016;49(2):202–206.

doi:10.5946/ce.2015.059

Для цитирования

Fedorina TA, Nedugov GV. Morphometric Differential Diagnosis of Intestinal Tuberculosis and Crohn's Disease. Science & Innovations in Medicine. 2018;3(11):5760.

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