Alzheimer’s disease as the cerebral cortex disorder


Objectives – to highlight the structure, function and localization of Alzheimer’s disease and to specify cognitive impairments related to it.

Material and methods. The anatomic data of human brain structure were used.

Results. The patterns of memory formation in the brain cortex are investigated. The brain cortex is presented as a type of syncytium consisting of elementary neural structures – cyclic neuronal circuits – memory elements. All cyclic neuronal circuits in a brain cortex are functionally interconnected. The connections between the neuronal circuits can be determined (imprinted) and stochastic (random). The intensity of stochastic communications defines the person's potential for creativity. The impairment of cyclic neuronal circuit connections results in either Alzheimer’s disease or in senile dementia of Alzheimer’s type. 

Conclusion. In case the cortex is considered as the syncytium, the memory storage element, it can be the reason of the human creativity. It is shown that the failure of the information transfer in the cortex syncytium or neurons destruction in the neuronal network results in Alzheimer’s disease or in senile dementia of Alzheimer’s type.

Conflict of Interest: nothing to disclose.

Список литературы

1. Guyton AC, Hall JE. Textbook of Medical Physiology. Elsevier Inc., New York, USA, 2006.

2. Carola R, Harley JP, Nobac C.R. Human Anatomy and Physiology. New York, London, Paris, McGraw-Hilll Publishing Company, 1990:380, 387.

3. Kositckii GI. Ed. [Human physiology]. M.: Meditcina, 1995:142. (In Russ.).

4. HubelD, StevensC, KandelE, etal. The Brain. Scientific American, September, 1979.

5. Rosenblatt F. The perceptron, a probabilistic model for information storage and organization in the brain. Psych. Rev.1958;65:386–408.

6. Hopfield JJ. Neural networks and physical systems with emergent collective computational abilities. Proceeding of the National Academy of Sciences USA. 1982;79:2554–2558.

7. Brown D, Rothery P. Models in Biology: Mathematics, Statistics, and Computing. Jon Wiley & Sons Ltd., Chichester, NY, 1994:618.

8. Masliah E, Mallory M, Hansen L. Quantitative synaptic alterations in the human neocortex during normal aging. Neurology. 1993;43:192–197.

9. Gibson PH. EM study of the number of cortical synapses in the brains of aging people and people with Alzheimer-type dementia. Acta Neuropathologica. 1983;62:127–133.

Для цитирования

Volobuev AN, Romanchuk PI, Bulgakova SV. Alzheimer’s disease as the cerebral cortex disorderScience & Innovations in Medicine.2019;4(2):16-20. DOI: 10.35693/2500-1388-2019-4-2-16-20


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