I.P. Pavlov Journal of Higher Nervous ActivityI.P. Pavlov Journal of Higher Nervous ActivityЖурнал высшей нервной деятельности им. И.П. Павлова0044-46773034-5316The Russian Academy of Sciences65200710.31857/S0044467723060138AUOCKZФИЗИОЛОГИЧЕСКИЕ МЕХАНИЗМЫ ПОВЕДЕНИЯ ЖИВОТНЫХ: ВОСПРИЯТИЕ ВНЕШНИХ СТИМУЛОВ, ДВИГАТЕЛЬНАЯ АКТИВНОСТЬ, ОБУЧЕНИЕ И ПАМЯТЬФИЗИОЛОГИЧЕСКИЕ МЕХАНИЗМЫ ПОВЕДЕНИЯ ЖИВОТНЫХ: ВОСПРИЯТИЕ ВНЕШНИХ СТИМУЛОВ, ДВИГАТЕЛЬНАЯ АКТИВНОСТЬ, ОБУЧЕНИЕ И ПАМЯТЬUnknownIncrease in histone acetylation rescues a weak remote fear memory in ratsУвеличение ацетилирования гистонов способствует восстановлению слабой отставленной памяти у крысVinarskayaA. Kh.ВинарскаяА. Х.lucky-a89@mail.ruBalabanP. M.БалабанП. М.lucky-a89@mail.ruZuzinaA. B.ЗюзинаА. Б.lucky-a89@mail.ruInstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of ScienceФедеральное государственное бюджетное учреждение науки Институт высшей нервной деятельности и нейрофизиологии РАН0111202373680981802022025Copyright ©; 2023, A.Kh. Vinarskaya, P.M. Balaban, A.B. ZuzinaCopyright ©; 2023, A.Kh. Vinarskaya, P.M. Balaban, A.B. Zuzina2023A.Kh. Vinarskaya, P.M. Balaban, A.B. ZuzinaA.Kh. Vinarskaya, P.M. Balaban, A.B. Zuzinahttps://innoscience.ru/0044-4677/article/view/652007

There is a growing body of evidence of memory-enhancing effects of histone deacetylase (HDAC) inhibitors in different species and models. Less clearly is understood whether the increased histone acetylation is able to facilitate the remote fear memory. Thus, the aim of the current study was to examine the ability of HDAC inhibitor sodium butyrate (SB) to ameliorate weakening of the remote fear memory in rats. To assess the ability of HDAC inhibitor SB to improve remote fear memory we compared the performance of two laboratory strains of rats, Wistar and Long-Evans, in context fear conditioning task six months after training before and after the SB administration. We found that the rats showed a strong fear response to the context 24 h after the end of conditioned fear training, full absence of fear after 6 months, and high fear response after the SB administration without additional learning. In control experiments, we found that time-dependent decrease in conditioned fear response to the context was similar in rats under vehicle administration. Moreover, the data obtained showed that both rats’ strains showed a similar decrease in freezing response over time, and HDAC inhibition improved the weak remote fear memory in both of them. In addition, the decrease in freezing and memory reinstatement by males matched completely to the female rats’ performance. These results indicate that HDAC inhibition appears to have the same “rescue” effects on remote fear memory reinstatement regardless of the strain and gender of rats.

Согласно современным представлениям ингибиторы гистондеацетилаз (ГДАЦ) способны улучшать память у различных видов животных. Однако до сих пор не ясно, может ли повышенное ацетилирование гистонов способствовать улучшению слабой отставленной памяти у крыс. Таким образом, целью настоящего исследования было изучение способности ингибитора ГДАЦ бутирата натрия (БН) улучшать слабую отставленную память о страхе у крыс. Чтобы оценить способность ингибитора ГДАЦ БН улучшать отставленную память, мы сравнили поведение двух лабораторных линий крыс, Wistar и Long-Evans, в задаче условно-рефлекторного страха через шесть месяцев после обучения до и после введения БН. Мы обнаружили, что животные демонстрировали хорошую обстановочную память через 24 ч после окончания обучения, полное отсутствие памяти через 6 мес. и улучшенную условно-рефлекторную память после введения БН без дополнительного обучения. Более того, полученные данные продемонстрировали, что обе линии крыс показали одинаковое снижение реакции замирания с течением времени, а ингибирование ГДАЦ улучшало слабую память у обеих линий. Кроме того, ослабление и восстановление памяти у самцов полностью соответствовало изменениям памяти у самок крыс. Эти результаты показывают, что ингибирование ГДАЦ оказывает одинаковый “восстанавливающий” эффект на слабую отставленную условно-рефлекторную память о страхе, независимо от линии и пола крыс.

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