I.P. Pavlov Journal of Higher Nervous ActivityI.P. Pavlov Journal of Higher Nervous ActivityЖурнал высшей нервной деятельности им. И.П. Павлова0044-46773034-5316The Russian Academy of Sciences65200810.31857/S0044467723060047SLNBWYЭКСПЕРИМЕНТАЛЬНАЯ ПАТОЛОГИЯ ВЫСШЕЙ НЕРВНОЙ ДЕЯТЕЛЬНОСТИЭКСПЕРИМЕНТАЛЬНАЯ ПАТОЛОГИЯ ВЫСШЕЙ НЕРВНОЙ ДЕЯТЕЛЬНОСТИDISORDERS OF MOTOR ACTIVITY ON THE MODEL OF AUTISM SPECTRUM DISORDERSНарушения двигательной активности на модели расстройств аутистического спектраKhairullinA. E.ХайруллинА. Е.khajrulli@yandex.ruEfimovaD. V.ЕфимоваД. В.khajrulli@yandex.ruIvanovaD. V.ИвановаД. В.khajrulli@yandex.ruBaltinaT. V.БалтинаТ. В.khajrulli@yandex.ruBaltinM. E.БалтинМ. Э.khajrulli@yandex.ruGrishinS. N.ГришинС. Н.khajrulli@yandex.ruZiganshinA. U.ЗиганшинА. У.khajrulli@yandex.ruKazan State Medical UniversityКазанский государственный медицинский университетKazan Federal UniversityКазанский Федеральный Университет0111202373681983202022025Copyright ©; 2023, А.Е. Хайруллин, Д.В. Ефимова, Д.В. Иванова, Т.В. Балтина, М.Э. Балтин, С.Н. Гришин, А.У. ЗиганшинCopyright ©; 2023, А.Е. Хайруллин, Д.В. Ефимова, Д.В. Иванова, Т.В. Балтина, М.Э. Балтин, С.Н. Гришин, А.У. Зиганшин2023А.Е. Хайруллин, Д.В. Ефимова, Д.В. Иванова, Т.В. Балтина, М.Э. Балтин, С.Н. Гришин, А.У. ЗиганшинА.Е. Хайруллин, Д.В. Ефимова, Д.В. Иванова, Т.В. Балтина, М.Э. Балтин, С.Н. Гришин, А.У. Зиганшинhttps://innoscience.ru/0044-4677/article/view/652008

Autism, or autism spectrum disorder (ASD), is a multifactorial disease that is characterized not only by disorders of the psycho-emotional state and social interaction, but also by somatic dysfunctions. A number of studies have also reported changes in the musculoskeletal system in patients with ASD. In this work, by the method of video analysis of movements, we demonstrated a decrease in horizontal and vertical motor activity, in addition, deviant movements were recorded, which indicates a violation in locomotor activity and increased anxiety in rats with a valproate model of autism. However, a mechano-myographic study did not reveal significant changes in the contractility parameters of isolated skeletal muscles of rats with the ASD model. Thus, it can be concluded that general differences in movement may be an independent factor in the diagnosis of autism. A more thorough study using a larger sample and detailed kinematic analysis can help in further assessing the variability of motor functions as a potential diagnostic and prognostic marker of ASD.

Аутизм, или расстройство аутистического спектра (РАС), является многофакторным заболеванием, которое характеризуется не только нарушениями психоэмоционального состояния и социального взаимодействия, но и соматическими дисфункциями. В ряде исследований также сообщалось об изменениях со стороны опорно-двигательной системы у пациентов с РАС. В данной работе методом видеоанализа движений мы продемонстрировали снижение горизонтальной и вертикальной двигательной активности, кроме этого, были зарегистрированы девиантные движения, что говорит о нарушении в локомоторной активности и повышенной тревожности крыс с вальпроатной моделью аутизма. Однако механо-миографическое исследование не выявило достоверных изменений в параметрах сократимости изолированных скелетных мышц крыс с моделью РАС. Таким образом, можно заключить, что общие различия в движении могут быть независимым фактором диагностики аутизма. Более тщательное исследование с использованием большей выборки и подробного кинематического анализа может помочь в дальнейшей оценке вариабельности двигательных функций, как потенциального диагностического и прогностического маркера РАС.

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