I.P. Pavlov Journal of Higher Nervous ActivityI.P. Pavlov Journal of Higher Nervous ActivityЖурнал высшей нервной деятельности им. И.П. Павлова0044-46773034-5316The Russian Academy of Sciences65206110.31857/S0044467724060023ОБЗОРЫ И ТЕОРЕТИЧЕСКИЕ СТАТЬИResearch ArticleTime and memoryПамять и времяBalabanP. M.БалабанП. М.
Russian Federation
borodinova.msu@mail.ruBorodinovaA. A.БородиноваА. А.
Russian Federation
borodinova.msu@mail.ruInstitute of Higher Nervous Activity and Neurophysiology of RASФедеральное государственное бюджетное учреждение науки «Институт высшей нервной деятельности и нейрофизиологии РАН»1112202474665766602022025Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://innoscience.ru/0044-4677/article/view/652061

In this review, based on our own and literature data, the temporal course of long-term memory formation, the duration of consolidation and reconsolidation processes, the temporal parameters of the interaction of glial and neuronal elements of the neural network, and possible mechanisms of neuro-glial interactions are analyzed. Based on the analysis, an assumption was made that allows us to explain the duration of the period of consolidation and reconsolidation of long-term memory (4–6 hours) by the need for the contribution of glia to the local epigenetic regulation of plasticity gene expression in the neurons of the memory engram.

В настоящем обзоре на основе собственных и литературных данных анализируется временное течение формирования долговременной памяти, длительность процессов консолидации и реконсолидации, временные параметры взаимодействия глиальных и нейрональных элементов нервной сети, возможные механизмы нейро-глиальных взаимодействий. На основе проведенного анализа выдвигается предположение, позволяющее объяснить длительность периода консолидации и реконсолидации долговременной памяти (4—6 часов) необходимостью вклада глиального окружения в локальные эпигенетические изменения экспрессии генов пластичности в нейронах энграммы памяти.

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