I.P. Pavlov Journal of Higher Nervous ActivityI.P. Pavlov Journal of Higher Nervous ActivityЖурнал высшей нервной деятельности им. И.П. Павлова0044-46773034-5316The Russian Academy of Sciences65207110.31857/S0044467724050032ОБЗОРЫ И ТЕОРЕТИЧЕСКИЕ СТАТЬИReview ArticleCentral neurophysiological mechanisms of stress resistance in post-traumatic stress disorderЦентральные нейробиологические механизмы стрессоустойчивости при посттравматическом стрессовом состоянииKondashevskayaM. V.КондашевскаяМ. В.
Russian Federation
actual_probl@mail.ruArtemyevaK. A.АртемьеваК. А.
Russian Federation
actual_probl@mail.ruAleksankinaV. V.АлексанкинаВ. В.
Russian Federation
actual_probl@mail.ruAvtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution Petrovsky National Research Centre of SurgeryНаучно-исследовательский институт морфологии человека им. академика А.П. Авцына ФГБНУ «Российский научный центр хирургии им. академика Б.В. Петровского»2611202474556559002022025Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://innoscience.ru/0044-4677/article/view/652071

Post-traumatic stress disorder (PTSD) is a severe, disabling syndrome that is induced by an extremely powerful negative impact on the people’s psyche. Symptoms of the disease most often do not appear in the entire population of stressed people and not immediately, but after some indefinite period of time. The disease is caused by central, genetic, epigenetic and neurobiological determinants, interactively integrated within the underlying social and natural-anthropogenic context. The simultaneous development of a pathological reaction from the hypothalamic-pituitary-adrenal, sympathoadrenal and immune systems was established. Information on the state of the main biogenic and amino acid neurotransmitters of the central nervous system in PTSD is presented. Researchers are currently focusing on peptide hormones such as brain-derived neurotrophic factor, neuropeptide Y, and leptin, which can be used to diagnose and treat PTSD. An analysis of the literature led to the conclusion that about the characteristics of stress-resistant people and animals very little is still known.

Посттравматическое стрессовое расстройство (ПТСР) – это тяжелый, инвалидизирующий синдром, который индуцируется экстремальным негативным воздействием на психику людей. Симптомы заболевания чаще всего проявляются не у всей популяции стрессированных и не сразу, а через некоторый неопределенный период времени. Заболевание обусловлено центральными генетическими, эпигенетическими и нейробиологическими детерминантами, интегрированными в основу социального и природно-антропогенного контекста. Установлено одновременное развитие патологической реакции со стороны гипоталамо-гипофизарно-адреналовой, симпатоадреналовой и иммунной систем. Рассмотрено состояние основных биогенных и аминокислотных нейромедиаторов ЦНС при ПТСР. В настоящее время внимание исследователей сосредоточено на таких пептидных гормонах, как нейротрофический фактор головного мозга, нейропептид Y и лептин, которые могут быть использованы для диагностики и лечения ПТСР. Анализ литературы позволил сделать вывод, что об особенностях стрессоустойчивости людей и животных известно пока очень мало.

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