I.P. Pavlov Journal of Higher Nervous ActivityI.P. Pavlov Journal of Higher Nervous ActivityЖурнал высшей нервной деятельности им. И.П. Павлова0044-46773034-5316The Russian Academy of Sciences65208510.31857/S0044467724040108МЕТОДИКАResearch ArticleDependency of amplitude and phase characteristics of vasomotor oscillations on visual stimulation conditions and experiment durationЗависимость амплитудных и фазовых характеристик вазомоторных колебаний от условий зрительной стимуляции и длительности проведения экспериментаKozhukhovS. A.КожуховС. А.
Russian Federation
sergei.kozhukhov@ihna.ruSaltykovK. A.СалтыковК. А.
Russian Federation
sergei.kozhukhov@ihna.ruBondarI. V.БондарьИ. В.
Russian Federation
sergei.kozhukhov@ihna.ruInstitute of Higher Nervous Activity and Neurophysiology of the Russian Academy of SciencesИнститут высшей нервной деятельности и нейрофизиологии РАНInstitute of Higher Nervous Activity and Neurophysiology of the Russian Academy of SciencesИнститут высшей нервной деятельности и нейрофизиологии Российской академии наук0911202474449651402022025Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://innoscience.ru/0044-4677/article/view/652085

The intrinsic-signal optical imaging is widely used in experimental, theoretical and applied research of the mammal’s brain neocortex functional anatomy. However, a neural activity signal is hidden by the background activity, the amplitude of which is an order of magnitude larger than the mapping signal amplitude. Most of such background activity represents spontaneous oscillations in 0.01–0.15 Hz frequency range related to vasomotor oscillations. In this paper, we point out that such oscillations change their power and phase during the response time course. The most dramatic influence is intrinsic for 0.05–0.15 Hz oscillations. The power of vasomotor oscillations declines more quickly than the stability features of their phase characteristics. Departing from these data, we suggested approaches for minimization of role of vasomotor oscillations in functional maps resulting from intrinsic-signal optical imaging.

Метод оптического картирования по внутреннему сигналу широко используется в экспериментальных, теоретических и прикладных исследованиях функциональной анатомии коры головного мозга млекопитающих. Однако регистрируемый сигнал, коррелирующий с нейронной активностью, маскируется фоновой активностью, которая может на порядок превышать величину картирующего сигнала. Большая часть фоновой активности состоит из спонтанных колебаний частотой от 0.01 до 0.15 Гц, называемых вазомоторными колебаниями. В данной работе мы показали, что эти колебания меняются в течение времени проведения эксперимента. Большему воздействию подвержены колебания в частотном диапазоне от 0.05 до 0.15 Гц. При этом мощность вазомоторных колебаний уменьшается более существенно, чем показатель стабильности их фазовых характеристик. В работе обсуждаются методические подходы по минимизации влияния вазомоторных колебаний на построенные методом оптического картирования функциональные карты.

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