I.P. Pavlov Journal of Higher Nervous ActivityI.P. Pavlov Journal of Higher Nervous ActivityЖурнал высшей нервной деятельности им. И.П. Павлова0044-46773034-5316The Russian Academy of Sciences65210410.31857/S0044467724010037ОБЗОРЫ И ТЕОРЕТИЧЕСКИЕ СТАТЬИReview ArticleParticipation of the subventricular zone of the brain in the development of brain gliomaУчастие субвентрикулярной зоны мозга в развитии глиомы головного мозгаRevishchinA. V.РевищинА. В.
Russian Federation
revishchin@mail.ruPavlovaG. V.ПавловаГ. В.
Russian Federation
revishchin@mail.ruInstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of SciencesФГБУН “Институт высшей нервной деятельности и нейрофизиологии Российской Академии Наук”N.N. Burdenko National Medical Research Center of Neurosurgery, Ministry of Healthcare of RussiaФГАУ “НМИЦ нейрохирургии им. академика Н. Н. Бурденко” Минздрава РоссииSechenov First Moscow State Medical UniversityПервый Московский государственный медицинский университет им. И. М. Сеченова10072024741263502022025Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://innoscience.ru/0044-4677/article/view/652104

Glioblastoma (GBM) is a malignant tumor with an average survival rate of 15–16 months with standard treatment; however, cases of successful treatment provide hope that a better understanding of the pathology will improve prognosis. Glial tumors contain clonogenic cells (cells capable of forming colonies in a culture medium) with a high proliferative potential, and their descendants have a wide range of possible differentiation; these clonogenic cells are currently considered as glioma stem cells (GSCs). In normal and pathological conditions, there are zones in the adult brain that contain proliferating neural stem cells (NSCs) and their descendants – progenitor cells that have begun to differentiate. One such zone lying on the lateral wall of the lateral ventricle, called the subventricular zone of the lateral ventricle (SVZ), has attracted much attention due to its importance for gliomagenesis. Numerous studies have shown that the intense exchange of signaling molecules and cells between the GBM and the SVZ leads to accelerated tumor growth and an increased risk of relapse. Research results indicate the possibility of developing new, more effective strategies to combat this dangerous disease, taking into account knowledge about the role of SVZ in the development of this pathology.

Глиобластома (ГБМ) – злокачественная опухоль со средней выживаемостью 15–16 месяцев при стандартном лечении; однако случаи успешного лечения дают надежду на то, что более глубокое понимание патологии улучшит прогноз. Глиальные опухоли содержат клоногенные клетки (клетки, способные образовывать колонии в культуральной среде) с высоким пролиферативным потенциалом, а их потомки обладают широким спектром возможной дифференцировки; данные клоногенные клетки в настоящее время рассматриваются как стволовые клетки глиомы (ГСК). В норме и патологии во взрослом мозге существуют зоны, которые содержат пролиферирующие нейральные стволовые клетки (НСК) и их потомки – начавшие дифференцировку прогениторные клетки. Одна из таких зон, лежащая на латеральной стенке бокового желудочка, называемая субвентрикулярной зоной бокового желудочка (СВЗ), привлекает большое внимание в связи с ее значением для глиомогенеза. Многочисленные исследования показали, что интенсивный обмен сигнальными молекулами и клетками между ГБМ и СВЗ приводит к ускорению роста опухоли и повышению риска рецидивов. Результаты исследований указывают на возможности разработки новых, более действенных стратегий борьбы с этим опасным заболеванием с учетом знаний о роли СВЗ в развитии этой патологии.

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