I.P. Pavlov Journal of Higher Nervous ActivityI.P. Pavlov Journal of Higher Nervous ActivityЖурнал высшей нервной деятельности им. И.П. Павлова0044-46773034-5316The Russian Academy of Sciences68757910.31857/S0044467725040075ФИЗИОЛОГИЧЕСКИЕ МЕХАНИЗМЫ ПОВЕДЕНИЯ ЖИВОТНЫХ: ВОСПРИЯТИЕ ВНЕШНИХ СТИМУЛОВ, ДВИГАТЕЛЬНАЯ АКТИВНОСТЬ, ОБУЧЕНИЕ И ПАМЯТЬФИЗИОЛОГИЧЕСКИЕ МЕХАНИЗМЫ ПОВЕДЕНИЯ ЖИВОТНЫХ: ВОСПРИЯТИЕ ВНЕШНИХ СТИМУЛОВ, ДВИГАТЕЛЬНАЯ АКТИВНОСТЬ, ОБУЧЕНИЕ И ПАМЯТЬResearch ArticleAssessment of the role of TAAR9 gene knockout in impulsive and compulsive behavior in ratsОценка импульсивности и компульсивности крыс с нокаутом по гену TAAR9 на модели аддиктивного поведенияSurovD. V.СуровД. В.
Russian Federation
surovd01@mail.ruLebedevA. A.ЛебедевА. А.
Russian Federation
surovd01@mail.ruPyurveevS. S.ПюрвеевС. С.
Russian Federation
surovd01@mail.ruZhukovI. S.ЖуковИ. С.
Russian Federation
surovd01@mail.ruGramotaK. E.ГрамотаK. Е.
Russian Federation
surovd01@mail.ruTraktirovD. S.ТрактировД. С.
Russian Federation
surovd01@mail.ruShabanovP. D.ШабановП. Д.
Russian Federation
surovd01@mail.ruInstitute of Experimental MedicineФГБНУ «Институт экспериментальной медицины»Saint Petersburg State Pediatric Medical UniversityФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет»Saint Petersburg State UniversityФГБОУ ВО «Санкт-Петербургский государственный университет»150820257544714821507202515072025Copyright ©; 2025, Russian Academy of SciencesCopyright ©; 2025, Российская академия наук2025Russian Academy of SciencesРоссийская академия наукhttps://innoscience.ru/0044-4677/article/view/687579

Trace amines and their receptors, in particular TAAR9, can act as potential regulators of the mechanisms of compulsivity and impulsivity, as addictive manifestations of behavior. The aim of this work was to evaluate the impulsive and compulsive components of the behavioral phenotype of rats with TAAR9 gene knockout. The assessment of impulsive behavioral elements was performed using the adapted Iowa Gambling Task (IGT). TAAR9-KO rats did not differ from wild-type rats in the IGT test and equally preferred the option associated with the greatest reward. The marble burying test was used to assess the compulsive component of behavior. The TAAR9-KO group demonstrated an increase in compulsive-like behavior compared to the control in the marble burying test. Thus, TAAR9-knockout rats demonstrate prerequisites for increased compulsive behavior, which is associated with the development of elements of gambling addiction.

Следовые амины и их рецепторы, в частности TAAR9, могут выступать в качестве потенциальных регуляторов механизмов компульсивности и импульсивности как аддиктивных проявлений поведения. Целью данной работы была оценка импульсивного и компульсивного компонентов поведенческого фенотипа крыс с нокаутом гена TAAR9. Оценку элементов импульсивности в поведении осуществляли при помощи адаптированного теста Iowa Gambling Task (IGT). Крысы TAAR9-KO не отличались от крыс дикого типа в тесте IGT и в равной степени предпочитали вариант, ассоциированный с наибольшим вознаграждением. Для оценки компульсивного компонента поведения использовали тест на закапывание шариков. Группа TAAR9-KO продемонстрировала повышение показателей компульсивноподобного поведения по сравнению с контролем в тесте закапывания шариков. Таким образом, TAAR9-нокаутные крысы демонстрируют предпосылки к повышенной компульсивности в поведении, что ассоциируется с развитием элементов игровой зависимости.

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