I.P. Pavlov Journal of Higher Nervous ActivityI.P. Pavlov Journal of Higher Nervous ActivityЖурнал высшей нервной деятельности им. И.П. Павлова0044-46773034-5316The Russian Academy of Sciences69642110.31857/S0044467725060021ФИЗИОЛОГИЯ ВЫСШЕЙ НЕРВНОЙ (КОГНИТИВНОЙ) ДЕЯТЕЛЬНОСТИ ЧЕЛОВЕКАФИЗИОЛОГИЯ ВЫСШЕЙ НЕРВНОЙ (КОГНИТИВНОЙ) ДЕЯТЕЛЬНОСТИ ЧЕЛОВЕКАResearch ArticleResting-state Network Functional Organization in Temporal Lobe Epilepsy: Effects of Comorbid DepressionОсобенности функциональной организации сетей покоя у пациентов с височной эпилепсией: Влияние коморбидной депрессииIerusalimskyN. V.ИерусалимскийН. В.e.d.karimova@gmail.comKarimovaE. D.КаримоваЕ. Д.e.d.karimova@gmail.comSamotaevaI. S.СамотаеваИ. С.e.d.karimova@gmail.comLuzinR. V.ЛузинР. В.e.d.karimova@gmail.comZinchukM. S.ЗинчукМ. С.e.d.karimova@gmail.comRiederF. K.РидерФ. К.e.d.karimova@gmail.comGuekhtA. B.ГехтА. Б.e.d.karimova@gmail.comLaboratory of Applied Human Higher Nervous Activity Physiology, Institute of Higher Nervous Activity and Neurophysiology, RASФГБУН Институт высшей нервной деятельности и нейрофизиологии РАНMoscow Research and Clinical Center for NeuropsychiatryГБУЗ Научно-практический психоневрологический центр им. З.П. Соловьева Департамента здравоохранения города МосквыPirogov Russian National Research Medical UniversityФГАОУ ВО “Российский национальный исследовательский медицинский университет им. Н.И. Пирогова” Министерства здравоохранения России15112025756VOL 75, NO6 (2025)ТОМ 75, №6 (2025)67869418112025Copyright ©; 2025, Russian Academy of SciencesCopyright ©; 2025, Российская академия наук2025Russian Academy of SciencesРоссийская академия наукhttps://innoscience.ru/0044-4677/article/view/696421

This study aimed to investigate resting-state network functional connectivity in patients with temporal lobe epilepsy (TLE) with and without comorbid depression. Using resting-state functional magnetic resonance imaging (rs-fMRI) and the XCP-D software package, we assessed functional connectivity between nodes of major resting-state neural networks: the default mode network (DMN), salience network (SN), dorsal attention network (DAN), somatomotor network (SMN), and frontoparietal control network (FPCN). The study included 77 patients with TLE (36 with depression, 41 without) and 48 healthy controls. Compared with both TLE without depression and healthy controls, patients with TLE and depression demonstrated decreased functional connectivity between key nodes of the SN, DAN, and DMN. In contrast, TLE without depression was characterized by increased connectivity between nodes of the DMN, FPCN, and SMN. A common feature for both TLE groups was increased connectivity between prefrontal nodes of the DMN and FPCN. These findings suggest distinct mechanisms of network reorganization in TLE depending on the presence of comorbid depression and highlight the importance of an integrative neuroimaging approach to epilepsy research.

Целью настоящего исследования было изучение функциональной коннективности сетей покоя у пациентов с височной эпилепсией (ВЭ) с коморбидной депрессией и без нее. С использованием метода функциональной МРТ в состоянии покоя (resting-state fMRI) и программного пакета XCP-D была проведена оценка функциональной коннективности между узлами основных нейрональных сетей покоя: сети пассивного режима работы (СПРР), сети выделения значимости (СВЗ), дорсальной сети внимания (ДСВ), сенсомоторной (СМС) и лобно-теменной контрольной (ЛТС) сетей. В исследовании приняли участие 77 пациентов с ВЭ (36 с депрессией, 41 без нее) и 48 здоровых испытуемых. У пациентов с ВЭ и депрессией по сравнению с пациентами с ВЭ без депрессии и с контрольной группой было обнаружено снижение функциональной коннективности между ключевыми узлами СВЗ, ДСВ и СПРР. Напротив, при ВЭ без депрессии наблюдалось усиление коннективности между отдельными узлами разных сетей покоя – СПРР, СМС и ЛТС – и снижение коннективности внутри одной сети покоя – СПРР. Общим для обеих групп пациентов с ВЭ стало увеличение коннективности между префронтальными узлами СПРР и ЛТС. Результаты свидетельствуют о наличии различных механизмов нейросетевой перестройки при ВЭ в зависимости от наличия коморбидной депрессии и подчеркивают значимость комплексного подхода к исследованию эпилепсии с использованием методов нейровизуализации.

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