Dehydroepiandrosterone (DHEA) and sexual function in men with chronic prostatitis


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Abstract

The aim of this study was to determine relationships between the level of DHEA-sulfate (DHEA-S), an erectile function and libido in men with chronic prostatitis. 53 patients (mean age 44.6±12.0; range
21-68 years) with chronic prostatitis were studied. Libido and erection were estimated and patients were divided into n»o groups according to their sexual dysfunction: 21 patients with severe sexual dysfunction (SSD) and 32 patients with mild sexual dysfunction (MSD). Testosterone, prolactin and DHEA-S were detected by ELISA. SSD patients had a lower testosterone level than patients with MSD (11.8±4.6 vs 14.8±5.9 nmol/1, respectively, p = 0.04) and DHEA-S (1.7+0.8 vs 2.5+1.2 microg/ml, respectively, p = 0.01). There was a negative correlation between the age of the patents and an erectile function (r = -0.70; p < 0.001), age and libido ir = -0.57; p < 0.001). The negative correlation was revealed between DHEA-S and age (r = -0.59; p < 0.001). A positive correlation »as between DHEA-S and an erectile function (r = 0.45. p = O.OOi i. There was no correlation between DHEA-S and serum testosterone te%ei t.r = 0.10; p = 0.5). Multiple regression analysis showed an independent positive correlation between DHEA-S and erectile function in patients with chronic prostatitis (p = 0.28; p = 0.02: R; = 0.401 The findings show that erectile dysfunction independently from aee s associated with a lower level of serum DHEA-S in patients with chronic prostatitis.

References

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