<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Science and Innovations in Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Science and Innovations in Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Наука и инновации в медицине</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2500-1388</issn><issn publication-format="electronic">2618-754X</issn><publisher><publisher-name xml:lang="en">FSBEI of Higher Education SamSMU of Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">21445</article-id><article-id pub-id-type="doi">10.35693/2500-1388-2017-0-4-13-17</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">BIOPHYSICAL BASES OF GENOME ORGANIZATION</article-title><trans-title-group xml:lang="ru"><trans-title>БИОФИЗИЧЕСКИЕ ОСНОВЫ ОРГАНИЗАЦИИ ГЕНОМА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Volobuev</surname><given-names>AN N</given-names></name><name xml:lang="ru"><surname>Волобуев</surname><given-names>А Н</given-names></name></name-alternatives><bio xml:lang="en"><p>PhD, Professor, head of the Department of medical physics, mathematics and informatics, Samara State Medical University.</p></bio><bio xml:lang="ru"><p>д.т.н., профессор, заведующий кафедрой физики, математики и информатики Самарского государственного медицинского университета.</p></bio><email>volobuev47@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Petrov</surname><given-names>ES S</given-names></name><name xml:lang="ru"><surname>Петров</surname><given-names>Е С</given-names></name></name-alternatives><bio xml:lang="en"><p>PhD, Associate Professor, associate professor of the Department of operative surgery and topographical anatomy with the course of innovative technologies, Samara State Medical University.</p></bio><bio xml:lang="ru"><p>к.м.н., доцент, доцент кафедры оперативной хирургии и топографической анатомии с курсом инновационных технологий Самарского государственного медицинского университета.</p></bio><email>petroves@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Romanchuk</surname><given-names>NP P</given-names></name><name xml:lang="ru"><surname>Романчук</surname><given-names>Н П</given-names></name></name-alternatives><bio xml:lang="en"><p>post-graduate student of the Department of physiology with the course of health and safety and disaster medicine, Samara State Medical University.</p></bio><bio xml:lang="ru"><p>аспирант физиологии с курсом безопасности жизнедеятельности и медицины катастроф Самарского государственного медицинского университета.</p></bio><email>romanchuknp@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Samara State Medical University</institution></aff><aff><institution xml:lang="ru">Самарский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2017</year></pub-date><volume>2</volume><issue>4</issue><issue-title xml:lang="en">NO4 (2017)</issue-title><issue-title xml:lang="ru">№4 (2017)</issue-title><fpage>13</fpage><lpage>17</lpage><history><date date-type="received" iso-8601-date="2020-03-10"><day>10</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Volobuev A.N., Petrov E.S., Romanchuk N.P.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, Волобуев А.Н., Петров Е.С., Романчук Н.П.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Volobuev A.N., Petrov E.S., Romanchuk N.P.</copyright-holder><copyright-holder xml:lang="ru">Волобуев А.Н., Петров Е.С., Романчук Н.П.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://innoscience.ru/2500-1388/article/view/21445">https://innoscience.ru/2500-1388/article/view/21445</self-uri><abstract xml:lang="en"><p>Aim - the analysis of nucleotide sequences of DNA molecules and the bases of the information storage with the help of DNA. Material and methods - the study is based on Markov chain theory and Bayesian Information Criterion. Results. Principles of genetic code construction were investigated. Specific nucleotide sequences were analyzed using Markov chain theory; the method of sequencing nucleotide sequences was described. Conclusion. A nucleotide sequence has certain restrictions associated with complementarity of the bases along DNA chain. These restrictions at the level of triplet sequence can be eliminated by degeneracy of the genetic code.</p></abstract><trans-abstract xml:lang="ru"><p>Цель - анализ нуклеотидных последовательностей молекул ДНК, основ хранения информации с помощью ДНК. Материалы и методы - использование теории цепей Маркова и информационного критерия Байеса. Результаты. Исследованы принципы построения генетического кода. Показана целесообразность вырождения генетического кода. На основе применения теории цепей Маркова дан анализ конкретных нуклеотидных последовательностей. Рассмотрен метод секвенирования нуклеотидной последовательности. Заключение. На последовательность нуклеотидов накладываются ограничения, связанные с комплементарностью оснований вдоль цепи ДНК. Эти ограничения на уровне последовательности кодонов могут в значительной мере сниматься вырожденностью генетического кода.</p></trans-abstract><kwd-group xml:lang="en"><kwd>genome</kwd><kwd>nucleotide sequence</kwd><kwd>Markov’s chains</kwd><kwd>Bayesian information criterion</kwd><kwd>sequencing</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>геном</kwd><kwd>нуклеотидная последовательность</kwd><kwd>цепи Маркова</kwd><kwd>информационный критерий Байеса</kwd><kwd>секвенирование</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Ленинджер А. Биохимия. Молекулярные основы структуры и функций клетки. М.: Мир, 1974.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Уотсон Дж. Молекулярная биология гена. М.: Мир, 1978</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Gamov GA. Possible Relation between Deoxyribonucleic Acid and Protein Structures. Nature 173 Feb 13(1954):318</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Резерфорд А. Биография жизни. От первой клетки до генной инженерии. М.: БИНОМ. Лаборатория знаний, 2016</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Козлов Н.Н. Математический анализ генетического кода. М.: БИНОМ, 2015</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Brown D., Rothery P. Models in Biology: Mathematics, Statistics, and Computing. Jon Wiley &amp; Sons Ltd., Chichester, NY, 1994</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Вейр Б. Анализ генетических данных. М: Мир, 1995</mixed-citation></ref></ref-list></back></article>
