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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Science and Innovations in Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Science and Innovations in Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Наука и инновации в медицине</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2500-1388</issn><issn publication-format="electronic">2618-754X</issn><publisher><publisher-name xml:lang="en">FSBEI of Higher Education SamSMU of Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">21565</article-id><article-id pub-id-type="doi">10.35693/2500-1388-2016-0-2-63-67</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">METHOD OF DIAGNOSIS OF ORAL MANIFESTATIONS OF HEMATOLOGIC MALIGNANCIES BY USING CONCENTRATIONS OF IMMUNOGLOBULIN A AND G ANTIBODIES TO GLIADINE AND TRANSGLUTAMINASE</article-title><trans-title-group xml:lang="ru"><trans-title>МЕТОД ДИАГНОСТИКИ СТОМАТИТОВ ПРИ ГЕМОБЛАСТОЗАХ ПО СОДЕРЖАНИЮ АНТИТЕЛ A И G К ГЛИАДИНУ И ТРАНСГЛУТАМИНАЗЕ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Svechnikova</surname><given-names>MV V</given-names></name><name xml:lang="ru"><surname>Свечникова</surname><given-names>М В</given-names></name></name-alternatives><bio xml:lang="en"><p>assistant of the Department of Therapeutic Dentistry, Samara State Medical University.</p></bio><bio xml:lang="ru"><p>ассистент кафедры терапевтической стоматологии СамГМУ.</p></bio><email>umka86@list.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gilmiyarov</surname><given-names>EM M</given-names></name><name xml:lang="ru"><surname>Гильмияров</surname><given-names>Э М</given-names></name></name-alternatives><bio xml:lang="en"><p>PhD, professor head of the Department of Therapeutic Dentistry, Samara State Medical University.</p></bio><bio xml:lang="ru"><p>заведующий кафедрой терапевтической стоматологии СамГМУ, д.м.н., профессор</p></bio><email>terstom-samara@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Selezneva</surname><given-names>IA A</given-names></name><name xml:lang="ru"><surname>Селезнева</surname><given-names>И А</given-names></name></name-alternatives><bio xml:lang="en"><p>PhD, associate professor of the Department of Fundamental and Clinical Biochemistry with Laboratory Diagnosis.</p></bio><bio xml:lang="ru"><p>доцент кафедры фундаментальной и клинической биохимии с лабораторной диагностикой, к.м.н.</p></bio><email>innola@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fedyaev</surname><given-names>IM M</given-names></name><name xml:lang="ru"><surname>Федяев</surname><given-names>И М</given-names></name></name-alternatives><bio xml:lang="en"><p>PhD, professor of the Department of the Oral and Maxillofacial Surgery.</p></bio><bio xml:lang="ru"><p>профессор кафедры челюстно-лицевой хирургии, д.м.н.</p></bio><email>terstom-samara@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Samara State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава РФ</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2016</year></pub-date><volume>1</volume><issue>2</issue><issue-title xml:lang="en">NO2 (2016)</issue-title><issue-title xml:lang="ru">№2 (2016)</issue-title><fpage>63</fpage><lpage>67</lpage><history><date date-type="received" iso-8601-date="2020-03-10"><day>10</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Svechnikova M.V., Gilmiyarov E.M., Selezneva I.A., Fedyaev I.M.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, Свечникова М.В., Гильмияров Э.М., Селезнева И.А., Федяев И.М.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Svechnikova M.V., Gilmiyarov E.M., Selezneva I.A., Fedyaev I.M.</copyright-holder><copyright-holder xml:lang="ru">Свечникова М.В., Гильмияров Э.М., Селезнева И.А., Федяев И.М.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://innoscience.ru/2500-1388/article/view/21565">https://innoscience.ru/2500-1388/article/view/21565</self-uri><abstract xml:lang="en"><p>Aim - developing of the new method of diagnosis of oral manifestations of hematologic malignancies by using concentrations of immunoglobulin A and G antibodies to gliadine and transglutaminase in saliva. Materials and methods. The condition of oral mucosa and concentrations of immunoglobulin A and G antibodies to gliadine and transglutaminase were assessed in 90 patients with acute and chronic leukemia. Results. After polychemiotherapy their oral status and concentrations of immunoglobulin A and G antibodies to gliadine and transglutaminase changed significantly. Conclusion. The study will help develop effective method of diagnosis of oral manifestations of hematologic malignancies.</p></abstract><trans-abstract xml:lang="ru"><p>Цель - внедрение нового метода диагностики стоматитов путем исследования содержания антител иммуноглобулинов А и G к глиадину и трансглутаминазе в ротовой жидкости. Материалы и методы. Состояние слизистой оболочки полости рта и содержание антител было оценено у 90 пациентов с острым и хроническим лейкозом. Результаты. После полихимиотерапии состояние слизистой оболочки полости рта и содержание антител существенно изменилось. Заключение. Данное исследование помогает разработать более эффективные методы диагностики проявления стоматитов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>acute myeloblastic and lymphoblastic leukemia</kwd><kwd>chronic lymphocytic and myelogenous leukemia</kwd><kwd>salivary markers</kwd><kwd>mucositis</kwd><kwd>polychemiotherapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>острый миелобластный и лимфобластный лейкоз</kwd><kwd>хронический лимфолейкоз и миелолей-коз</kwd><kwd>маркеры в ротовой жидкости</kwd><kwd>мукозит</kwd><kwd>полихимиотерапия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Сахапова Г.Ф. Хемилюминесценция ротовой жидкости в диагностике язвенно- некротических поражений слизистой оболочки полости рта у пациентов с множественной миеломой. Клиническая стоматология. 2011(2):84-86</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Трухан Д.И. 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