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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Science and Innovations in Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Science and Innovations in Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Наука и инновации в медицине</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2500-1388</issn><issn publication-format="electronic">2618-754X</issn><publisher><publisher-name xml:lang="en">FSBEI of Higher Education SamSMU of Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">344062</article-id><article-id pub-id-type="doi">10.35693/2500-1388-2023-8-3-169-175</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Gerontology and geriatrics</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Геронтология и гериатрия</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Dependence in instrumental activities of daily living and its associations with other geriatric syndromes in people over 65 years of age: data from the Russian epidemiological study EUCALYPT</article-title><trans-title-group xml:lang="ru"><trans-title>Инструментальная зависимость в повседневной жизни и ее ассоциации с другими гериатрическими синдромами у лиц старше 65 лет: данные российского эпидемиологического исследования ЭВКАЛИПТ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6465-4842</contrib-id><name-alternatives><name xml:lang="en"><surname>Sharashkina</surname><given-names>Natalya V.</given-names></name><name xml:lang="ru"><surname>Шарашкина</surname><given-names>Наталья Викторовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Head of the Laboratory of General Geriatrics, Russian Gerontology Clinical Research Center</p></bio><bio xml:lang="ru"><p>канд. мед. наук, заведующая лабораторией общей гериатрии, ОСП «Российский геронтологический научно-клинический центр»</p></bio><email>sharashkina@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6021-7864</contrib-id><name-alternatives><name xml:lang="en"><surname>Vorobyeva</surname><given-names>Natalya M.</given-names></name><name xml:lang="ru"><surname>Воробьева</surname><given-names>Н. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Head of the Laboratory of Cardiovascular Aging, Russian Gerontology Clinical Research Center</p></bio><bio xml:lang="ru"><p>д-р мед. наук, заведующая лабораторией сердечно-сосудистого старения, ОСП «Российский геронтологический научно-клинический центр»</p></bio><email>vorobyeva_nm@rgnkc.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6530-932X</contrib-id><name-alternatives><name xml:lang="en"><surname>Permikina</surname><given-names>Irina V.</given-names></name><name xml:lang="ru"><surname>Пермикина</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>researcher at the Laboratory of General Geriatrics, Russian Gerontology Clinical Research Center</p></bio><bio xml:lang="ru"><p>научный сотрудник лаборатории общей гериатрии, ОСП «Российский геронтологический научно-клинический центр»</p></bio><email>Permikina_iv@rgnkc.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6623-6815</contrib-id><name-alternatives><name xml:lang="en"><surname>Selezneva</surname><given-names>Elena V.</given-names></name><name xml:lang="ru"><surname>Селезнева</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, senior researcher</p></bio><bio xml:lang="ru"><p>канд. экон. наук, старший научный сотрудник</p></bio><email>evselezneva@hse.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7266-707X</contrib-id><name-alternatives><name xml:lang="en"><surname>Ovcharova</surname><given-names>Liliya N.</given-names></name><name xml:lang="ru"><surname>Овчарова</surname><given-names>Л. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, vice-rector</p></bio><bio xml:lang="ru"><p>д-р экон. наук, проректор</p></bio><email>lovcharova@hse.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9666-9224</contrib-id><name-alternatives><name xml:lang="en"><surname>Popov</surname><given-names>Evgenii E.</given-names></name><name xml:lang="ru"><surname>Попов</surname><given-names>Е. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>a resident doctor, Russian Gerontology Clinical Research Center</p></bio><bio xml:lang="ru"><p>ординатор, ОСП «Российский геронтологический научно-клинический центр»</p></bio><email>rgnkc@rgnkc.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1628-5093</contrib-id><name-alternatives><name xml:lang="en"><surname>Kotovskaya</surname><given-names>Yuliya V.</given-names></name><name xml:lang="ru"><surname>Котовская</surname><given-names>Ю. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Professor, Deputy Director for research, Russian Gerontology Clinical Research Center</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор, заместитель директора по научной работе, ОСП «Российский геронтологический научно-клинический центр»</p></bio><email>kotovskaya_yv@rgnkc.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4193-688X</contrib-id><name-alternatives><name xml:lang="en"><surname>Tkacheva</surname><given-names>Olga N.</given-names></name><name xml:lang="ru"><surname>Ткачева</surname><given-names>О. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Professor, Director, Russian Gerontology Clinical Research Center</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор, директор, ОСП «Российский геронтологический научно-клинический центр»</p></bio><email>tkacheva@rgnkc.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Pirogov Russian National Research Medical University</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">National Research University Higher School of Economics</institution></aff><aff><institution xml:lang="ru">Национальный исследовательский университет «Высшая школа экономики»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-09-08" publication-format="electronic"><day>08</day><month>09</month><year>2023</year></pub-date><volume>8</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>169</fpage><lpage>175</lpage><history><date date-type="received" iso-8601-date="2023-04-24"><day>24</day><month>04</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-06-05"><day>05</day><month>06</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Sharashkina N.V., Vorobyeva N.M., Permikina I.V., Selezneva E.V., Ovcharova L.N., Popov E.E., Kotovskaya Y.V., Tkacheva O.N.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Шарашкина Н.В., Воробьева Н.М., Пермикина И.В., Селезнева Е.В., Овчарова Л.Н., Попов Е.Е., Котовская Ю.В., Ткачева О.Н.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Sharashkina N.V., Vorobyeva N.M., Permikina I.V., Selezneva E.V., Ovcharova L.N., Popov E.E., Kotovskaya Y.V., Tkacheva O.N.</copyright-holder><copyright-holder xml:lang="ru">Шарашкина Н.В., Воробьева Н.М., Пермикина И.В., Селезнева Е.В., Овчарова Л.Н., Попов Е.Е., Котовская Ю.В., Ткачева О.Н.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://innoscience.ru/2500-1388/article/view/344062">https://innoscience.ru/2500-1388/article/view/344062</self-uri><abstract xml:lang="en"><p><bold>Aim</bold> – to assess the frequency of disability in instrumental activities of daily living (IADLs) and to analyze its associations with other geriatric syndromes in persons aged ≥65 years.</p> <p><bold>Material and methods.</bold> The study involved 4,308 people (30% male) living in 11 regions of the Russian Federation, aged 65 to 107 years (average age 78 ± 8 years). The majority (60%) of participants were examined in a polyclinic, every fifth – in a hospital (20%) or at home (19%), 1% – in nursing homes. All patients underwent a comprehensive geriatric assessment, including an assessment of instrumental activities of daily living on the Lawton scale.</p> <p><bold>Results.</bold> Among the elderly, a high (54%) prevalence of dependence in IADLs was revealed, and with increasing age, this indicator increased significantly, reaching 82% in people over 85 years old. In patients with disability in IADLs, the frequency of all geriatric syndromes, except orthostatic hypotension, was higher, of which the most common were chronic pain syndrome (90%), frailty (80%), dependence in basic activities of daily living (ADLs) (78%), cognitive impairment (75%), probable depression (63%) and urinary incontinence (54%). One-factor regression analysis showed that the presence of disability in IADLs increases the chances of detecting other geriatric syndromes by 1.6–5.9 times.</p> <p><bold>Conclusion.</bold> The results of the EUCALYPT epidemiological study demonstrate a high prevalence of dependence in IADLs among the Russian population. The study also gives an idea of the relationship of dependence in IADLs with various geriatric syndromes.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Цель</bold> – оценить частоту инструментальной зависимости в повседневной жизни и проанализировать ее ассоциации с другими гериатрическими синдромами у лиц в возрасте ≥65 лет.</p> <p><bold>Материал и методы.</bold> В исследовании принимали участие 4 308 человек (30% мужчин), проживающие в 11 регионах РФ, в возрасте от 65 до 107 лет (средний возраст 78 ± 8 лет). Большинство (60%) участников были обследованы в условиях поликлиники, каждый пятый – в стационаре (20%) или на дому (19%), 1% – в интернатах/домах престарелых. Всем пациентам выполнили комплексную гериатрическую оценку, включая оценку инструментальной повседневной активности по шкале Лоутон.</p> <p><bold>Результаты.</bold> Среди пожилых людей выявлена высокая (54%) распространенность инструментальной зависимости в повседневной жизни, и с увеличением возраста этот показатель значительно возрастает, достигая 82% у лиц старше 85 лет. У пациентов с инструментальной зависимостью в повседневной жизни оказалась выше частота всех гериатрических синдромов (за исключением ортостатической гипотензии), из которых самыми распространенными были хронический болевой синдром (90%), синдром старческой астении (80%), базовая зависимость в повседневной жизни (78%), когнитивные нарушения (75%), вероятная депрессия (63%) и недержание мочи (54%). Однофакторный регрессионный анализ показал, что наличие инструментальной повседневной зависимости повышает шансы выявления других гериатрических синдромов в 1,6–5,9 раза.</p> <p><bold>Выводы.</bold> Результаты эпидемиологического исследования ЭВКАЛИПТ демонстрируют высокую распространенность зависимости в инструментальной повседневной активности среди российской популяции. Также исследование дает представление о взаимосвязи инструментальной зависимости с различными гериатрическими синдромами.</p></trans-abstract><kwd-group xml:lang="en"><kwd>instrumental activities of daily living</kwd><kwd>frailty</kwd><kwd>geriatric syndromes</kwd><kwd>older adults</kwd><kwd>dependence in basic activities of daily living</kwd><kwd>geriatric assessment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>инструментальная зависимость</kwd><kwd>старческая астения</kwd><kwd>гериатрические синдромы</kwd><kwd>пожилой пациент</kwd><kwd>базовая зависимость в повседневной жизни</kwd><kwd>комплексная гериатрическая оценка</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Lawton MP, Brody EM. Assessment of older people: Self-maintaining and instrumental activities of daily living. 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