Science and Innovations in MedicineScience and Innovations in Medicine2500-13882618-754XFSBEI of Higher Education SamSMU of Ministry of Health of the Russian Federation4373510.35693/2500-1388-2019-4-1-16-19Research ArticleNew prognostic method for estimation of lipid distress syndrome development in patients with chronic hepatitis CKonstantinovDmitrii Yur'evich<p>PhD, Associate Professor of the Chair of Infectious Diseases with a course of epidemiology of SamSMU</p>dk.samgmu@mail.ruhttps://orcid.org/0000-0002-6177-8487NedugovGerman V.<p>PhD, Head of the Forensic Histology Department of Samara Regional Bureau of Forensic Medical Expertise</p>nedugovh@mail.ruhttps://orcid.org/0000-0002-7380-3766PopovaLarisa L.<p>PhD, Professor of the Chair of Infectious Diseases with a course of epidemiology of SamSMU</p>infect.samgmu@mail.ruKonstantinovaElena A.<p>PhD, Associate Professor of the Chair of Infectious Diseases with a course of epidemiology of SamSMU</p>a.konstanta@mail.ruhttps://orcid.org/0000-0002-6022-0983Samara State Medical UniversitySamara Regional Bureau of Forensic Medical Expertise1503201941161908092020Copyright © 2019, Konstantinov D.Y., Nedugov G.V., Popova L.L., Konstantinova E.A.2019<p><strong>Objectives</strong> to work out a prognostic method, based on clinical and laboratory data, which can predict the development of lipid distress syndrome in patients with chronic viral hepatitis C.</p>
<p><strong>Material and methods.</strong>We studied the outcomes of chronic viral hepatitis C with respect to development of lipid distress syndrome in 267 patients who did not receive antiviral therapy during the observation period lasting for 1 to 7 years.</p>
<p><strong>Results.</strong>Discriminant function analysis of the data acquired after examination of 167 patients helped us to work out a discriminative model of predicting the development of lipid distress syndrome in patients with chronic viral hepatitis C in the absence of antiviral therapy. Cross-checking of prediction accuracy was carried out on the data of examination of other 100 patients.</p>
<p><strong>Conclusion.</strong>The designed technique for predicting the development of lipid distress syndrome in patients with chronic hepatitis C is characterized by point estimates of sensitivity and prognostic value of the negative result equal to 100%.</p>lipid distress syndromechronic viral hepatitis Cprognosisdiscriminant analysisлипидный дистресс-синдромхронический гепатит Спрогнозированиедискриминантный анализ[Константинов Д.Ю., Попова Л.Л., Голик О.О. Хронический вирусный гепатит С и состояние гепатобилиарной системы. Самара, 2018. [Konstantinov DYu, Popova LL, Golik OO. Khronicheski i virusnyi gepatit C i sostoyanie gepatobiliarnoi sistemy. Samara, 2018. (In Russ.)].][Ткаченко Л.И., Малеев В.В., Сариева Д.М. Нарушение липидного обмена у больных хроническим гепатиом С. Архив внутренней медицины. 2015;6(26):50–6. [Tkachenko LI, Ma-leev VV, Sarieva DM. Lipid metabolism disorders in patients with chronic hepatitis C. Arkhiv vnutrennei meditsiny. 2015;6(26):50–6. (In Russ.)].][Савельев В.С., Петухов В.А. Липидный дистресс-синдром. М., 2010. [Savel'ev VS, Petukhov VA. Lipidnyi distress-sindrom. Мoscow, 2010. (In Russ.)].][Константинов Д.Ю., Недугов Г.В., Суздальцев А.А., Константинова Е.А. Прогнозирование развития липидного дистресс-синдрома при хроническом вирусном гепатите С. Инфекционные болезни. 2018;16(4):34–37. [Konstantinov DYu, Nedugov GV, Suzdaltsev AA, Konstantinova EA. Prognosis of the development of lipid distress syndrome in chronic viral hepatitis C. Infektsionnye bolezni. 2018;16(4):34–37. (In Russ.)]. doi: 10.20953/1729-9225-2018-4-34-37]