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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Science and Innovations in Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Science and Innovations in Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Наука и инновации в медицине</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2500-1388</issn><issn publication-format="electronic">2618-754X</issn><publisher><publisher-name xml:lang="en">FSBEI of Higher Education SamSMU of Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">43739</article-id><article-id pub-id-type="doi">10.35693/2500-1388-2019-4-1-20-25</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Cardiology</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Кардиология</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Risk factors in patients with familial hypercholesterolemia: risk stratification and treatment tactics</article-title><trans-title-group xml:lang="ru"><trans-title>Вклад факторов риска в стратификацию риска пациентов с семейной гиперхолестеринемией и тактику их лечения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4391-6687</contrib-id><name-alternatives><name xml:lang="en"><surname>Simerzin</surname><given-names>Vasilii Vasilievich</given-names></name><name xml:lang="ru"><surname>Симерзин</surname><given-names>Василий Васильевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Professor of the Faculty Therapy Department, SamSMU</p></bio><bio xml:lang="ru"><p>д.м.н., профессор кафедры факультетской терапии СамГМУ</p></bio><email>simerzi@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7492-8045</contrib-id><name-alternatives><name xml:lang="en"><surname>Krasovskaya</surname><given-names>Margarita A.</given-names></name><name xml:lang="ru"><surname>Красовская</surname><given-names>М. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>general practitioner in Clinics of SamSMU</p></bio><bio xml:lang="ru"><p>врач-терапевт клиники факультетской терапии СамГМУ</p></bio><email>geliosmax@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gagloev</surname><given-names>Anton V.</given-names></name><name xml:lang="ru"><surname>Гаглоев</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>student Samara State Medical University</p></bio><bio xml:lang="ru"><p>студент группы научно-педагогического резерва СамГМУ</p></bio><email>anton-gaglo@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Samara State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2019-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2019</year></pub-date><volume>4</volume><issue>1</issue><issue-title xml:lang="en">VOL 4, NO1 (2019)</issue-title><issue-title xml:lang="ru">ТОМ 4, №1 (2019)</issue-title><fpage>20</fpage><lpage>25</lpage><history><date date-type="received" iso-8601-date="2020-09-08"><day>08</day><month>09</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2019, Simerzin V.V., Krasovskaya M.A., Gagloev A.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2019, Симерзин В.В., Красовская М.А., Гаглоев А.В.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="en">Simerzin V.V., Krasovskaya M.A., Gagloev A.V.</copyright-holder><copyright-holder xml:lang="ru">Симерзин В.В., Красовская М.А., Гаглоев А.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://innoscience.ru/2500-1388/article/view/43739">https://innoscience.ru/2500-1388/article/view/43739</self-uri><abstract xml:lang="en"><p>This review focuses on traditional and occasional risk factors in patients with familial hypercholesterolemia (FH) that influence their medical condition along with the level of the extreme hypercholesterolemia and their age (time of exposure to hypercholesterolemia).</p> <p>The risk factors in question can define the patients' stratification in groups of high and extreme risk, assist in treatment tactics and strategy.</p></abstract><trans-abstract xml:lang="ru"><p>В обзорной статье отмечено, что клиническое состояние пациентов с семейной гиперхолестеринемией и его прогноз определяется не только уровнем самой экстремальной гиперхолестеринемии, возрастом (временем экспозиции ГХС), но и наличием других традиционных и дополнительных факторов риска.</p> <p>Учет этих факторов позволяет проводить риск-страти-фикацию пациентов с выделением групп высокого и очень высокого риска, а также дает возможность намечать стратегию и тактику их ведения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>risk factors</kwd><kwd>familial hyperchole-sterolemia</kwd><kwd>risk stratification</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>факторы риска</kwd><kwd>семейная гиперхолестеринемия</kwd><kwd>стратификация риска</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Ference BA, Ginsberg HN, Graham I at al. 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