Science and Innovations in MedicineScience and Innovations in MedicineНаука и инновации в медицине2500-13882618-754XFSBEI of Higher Education SamSMU of Ministry of Health of the Russian Federation4374010.35693/2500-1388-2019-4-3-15-18HygieneГигиенаResearch ArticlePolymorphism of C/T-13910 lactase gene and anthropometric data of girls born in SamaraПолиморфизм гена лактазы С/Т-13910 и антропометрические данные девочек, рожденных в городе Самареhttps://orcid.org/0000-0003-3390-8034SpiridonovaNatalia V.СпиридоноваНаталья Владимировна
Russian Federation

PhD, Professor, Head of the Department of Obstetrics and Gynecology of the Institute of Postgraduate Education

д.м.н., профессор, заведующая кафедрой акушерства и гинекологии ИПО

nvspiridonova@mail.ruhttps://orcid.org/0000-0002-4130-492XSazonovaOlga V.СазоноваО. В.
Russian Federation

PhD, Associate Professor, Head of the Department of food hygiene with the course of hygiene of children and adolescents

д.м.н., доцент, заведующая кафедрой гигиены питания с курсом гигиены детей и подростков

nvspiridonova@mail.ruhttps://orcid.org/0000-0002-3929-4187BezrukovaAlina A.БезруковаА. А.
Russian Federation

assistant of the Department of food hygiene with the course of hygiene of children and adolescents

ассистент кафедры гигиены питания с курсом гигиены детей и подростков

nvspiridonova@mail.ruSamara State Medical UniversityФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России1509201943VOL 4, NO3 (2019)ТОМ 4, №3 (2019)151808092020Copyright ©; 2019, Spiridonova N.V., Sazonova O.V., Bezrukova A.A.Copyright ©; 2019, Спиридонова Н.В., Сазонова О.В., Безрукова А.А.2019Spiridonova N.V., Sazonova O.V., Bezrukova A.A.Спиридонова Н.В., Сазонова О.В., Безрукова А.А.https://creativecommons.org/licenses/by/4.0https://innoscience.ru/2500-1388/article/view/43740

Objectives –to assess the prevalence of C/T-13910 polymorphism of the lactase gene in the population of children in Samara and to identify the relationship with height, body weight and body mass index.

Material and methods. The study included 103 girls aged 3–6 years. Their height and body weight were measured, and buccal samples were taken to genotype lactase activity (determining the C/T-13910 variant).

Results. In girls born and living in Samara, the frequency of allele 13910-T was 48.6%. The СС genotype was detected in 51.4%, the СT genotype in 37.9% and the TT genotype in 10.7%. There was no statistically significant relationship between genotype and body weight and height, but all children with the TT genotype had a height of more than 25 percentiles, the vast majority of overweight and obese girls (91%) had the СС genotype or the СT genotype.

Цель – оценить распространенность полиморфизма C/T-13910 гена лактазы в популяции детей г. Самары и выявить взаимосвязь с ростом, массой тела и индексом массы тела.

Материал и методы. В исследование были включены 103 девочки в возрасте 3–6 лет. У них измеряли рост и массу тела, а также брали буккальные образцы для генотипирования активности лактазы (определения варианта C/T-13910).

Результаты. У девочек, рожденных и проживающих в г. Самаре, частота аллеля 13910-Т составила 48,6%. Генотип СС выявлен у 51,4%, генотип СТ – у 37,9% и генотип ТТ – у 10,7%. Не выявлено статистически значимой взаимосвязи между генотипом и массой тела и ростом, однако все дети с генотипом ТТ имели рост свыше 25 перцентиля, подавляющее большинство девочек с избыточной массой тела и ожирением (91%) имели генотип СС или генотип СТ.

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