Science and Innovations in MedicineScience and Innovations in Medicine2500-13882618-754XFSBEI of Higher Education SamSMU of Ministry of Health of the Russian Federation4374010.35693/2500-1388-2019-4-3-15-18Research ArticlePolymorphism of C/T-13910 lactase gene and anthropometric data of girls born in SamaraSpiridonovaNatalia V.<p>PhD, Professor, Head of the Department of Obstetrics and Gynecology of the Institute of Postgraduate Education</p>nvspiridonova@mail.ruhttps://orcid.org/0000-0003-3390-8034SazonovaOlga V.<p>PhD, Associate Professor, Head of the Department of food hygiene with the course of hygiene of children and adolescents</p>nvspiridonova@mail.ruhttps://orcid.org/0000-0002-4130-492XBezrukovaAlina A.<p>assistant of the Department of food hygiene with the course of hygiene of children and adolescents</p>nvspiridonova@mail.ruhttps://orcid.org/0000-0002-3929-4187Samara State Medical University1509201943151808092020Copyright © 2019, Spiridonova N.V., Sazonova O.V., Bezrukova A.A.2019<p><strong>Objectives</strong>to assess the prevalence of C/T-13910 polymorphism of the lactase gene in the population of children in Samara and to identify the relationship with height, body weight and body mass index.</p>
<p><strong>Material and methods.</strong>The study included 103 girls aged 36 years. Their height and body weight were measured, and buccal samples were taken to genotype lactase activity (determining the C/T-13910 variant).</p>
<p><strong>Results.</strong>In girls born and living in Samara, the frequency of allele 13910-T was 48.6%. The СС genotype was detected in 51.4%, the СT genotype in 37.9% and the TT genotype in 10.7%. There was no statistically significant relationship between genotype and body weight and height, but all children with the TT genotype had a height of more than 25 percentiles, the vast majority of overweight and obese girls (91%) had the СС genotype or the СT genotype.</p>lactase genotypeheightweightbody mass indexгенотип лактазыроствесиндекс массы тела[Buzás G, Fodor F, Csókay B. Accuracy of lactase gene C/T-13910 polymorphism and hydrogen breath test in a gastroenterology outpatient clinic: a retrospective study. Orv Hetil. 2016;157(25):1007–12. (In Hungarian). doi: 10.1556/650.2016.30462][Enko D, Rezanka E, Stolba R, Halwachs-Baumann G. Lactose malabsorption testing in daily clinical practice: a critical retrospective analysis and comparison of the hydrogen/methane breath test and genetic test (c/t-13910 polymorphism) results. Gastroenterol Res Pract. 2014;2014:464382. doi: 10.1155/2014/464382][Gerbault P. The onset of lactase persistence in Europe. Hum Hered. 2013;76(3-4):154–61. doi: 10.1159/000360136][Ranciaro A, Campbell MC, Hirbo JB, et al. Genetic origins of lactase persistence and the spread of pastoralism in Africa. The American Journal of Human Genetics. doi: 10.1016/j.ajhg.2014.02.009][Fang L, Ahn JK, Wodziak D, Sibley E. The human lactase persistence-associated SNP -13910*T enables in vivo functional persistence of lactase promoter-reporter transgene expression. Hum Genet. 2012;131(7):1153–9. doi: 10.1007/s00439-012-1140-z][Smith GD, Lawlor DA, Timpson NJ. Lactase persistence-related genetic variant: population substructure and health outcomes. Eur J Hum Genet. 2009;17(3):357–67. doi: 10.1038/ejhg.2008.156][Khabarova Y, Grigoryeva V, Tuomisto S, et al. High prevalence of lactase non-persistence among indigenous nomadic Nenets, north-west Russia. Int J Circumpolar Health. 2012;71:1–6. doi: 10.3402/ijch.v71i0.17898][Khabarova Y, Torniainen S, Nurmi H, et al. Prevalence of lactase persistent/non-persistent genotypes and milk consumption in a young population in north-west Russia. World J Gastroenterol. 2009; 15(15):1849–53. doi: 10.3748/wjg.15.1849][Mendelian randomization of dairy consumption working group. Dairy consumption and body mass index among adults: mendelian randomization analysis of 184802 individuals from 25 studies. Clin Chem. 2018;64(1):183–191. doi: 10.1373/clinchem.2017.280701][Manco L, Dias H, Muc M, Padez C. The lactase -13910C>T polymorphism (rs4988235) is associated with overweight/obesity and obesity-related variables in a population sample of Portuguese young adults. Eur J Clin Nutr. 2017;71(1):21–24. doi: 10.1038/ejcn.2016.164][Almon R, Álvarez-León EE, Serra-Majem L. Association of the European lactase persistence variant (LCT-13910 C>T polymorphism) with obesity in the Canary Islands. PLoS One. 2012;7(8):e43978. doi: 10.1371/journal.pone.0043978][Tolonen S1, Laaksonen M, Mikkilä V, et al. Cardiovascular risk in young finns study group. Lactase gene c/t(-13910) polymorphism, calcium intake, and pQCT bone traits in Finnish adults. Calcif Tissue Int. 2011 Feb;88(2):153–61. doi: 10.1007/s00223-010-9440-6][Almon R, Nilsson TK, Sjöström M, Engfeldt P. Lactase persistence and milk consumption are associated with body height in Swedish preadolescents and adolescents. Food Nutr Res. 2011;55. doi: 10.3402/fnr.v55i0.7253][Albuquerque D, Nóbrega C, Manco L. The lactase persistence -13910C>T polymorphism shows indication of association with abdominal obesity among Portuguese children. Acta Paediatr. 2013;102(4):e153–7. doi: 10.1111/apa.12134][Almon R, Patterson E, Nilsson TK, Engfeldt P, Sjöström M. Body fat and dairy product intake in lactase persistent and non-persistent children and adolescents. Food Nutr Res. 2010;54. doi: 10.3402/fnr.v54i0.5141]