Science and Innovations in MedicineScience and Innovations in MedicineНаука и инновации в медицине2500-13882618-754XFSBEI of Higher Education SamSMU of Ministry of Health of the Russian Federation4374310.35693/2500-1388-2019-4-1-26-31CardiologyКардиологияResearch ArticlePharmacoeconomics of treatment patients with high level hypercholesterolemiaФармакоэкономика эффективности лечения пациентов с высоким уровнем гиперхолестеринемииhttps://orcid.org/0000-0002-4928-5989FatenkovOleg VeniaminovichФатенковОлег Вениаминович
Russian Federation

PhD, Associate Professor,Head of the Faculty Therapy Department of SamSMU

д.м.н., доцент, заведующий кафедрой факультетской терапии СамГМУ

kdmc@mail.ruPanishevaYana A.ПанишеваЯ. А.
Russian Federation

general practitioner in Clinics of SamSMU

врач-терапевт клиники факультетской терапии СамГМУ

jana.panisheva@mail.ruhttps://orcid.org/0000-0002-9316-4957GalkinaMariya A.ГалкинаМ. А.
Russian Federation

teaching assistant of the Faculty Therapy Department of SamSMU

ассистент кафедры факультетской терапии СамГМУ

mkmkmk1977@mail.ruhttps://orcid.org/0000-0003-0775-5740SytdykovIl'nar Kh.СытдыковИ. Х.
Russian Federation

senior laboratorian of the Faculty Therapy Department of SamSMU

старший лаборант кафедры факультетской терапии СамГМУ

vampirecool@rambler.ruSamara State Medical UniversityФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России1503201941VOL 4, NO1 (2019)ТОМ 4, №1 (2019)263108092020Copyright ©; 2019, Fatenkov O.V., Panisheva Y.A., Galkina M.A., Sytdykov I.K.Copyright ©; 2019, Фатенков О.В., Панишева Я.А., Галкина М.А., Сытдыков И.Х.2019Fatenkov O.V., Panisheva Y.A., Galkina M.A., Sytdykov I.K.Фатенков О.В., Панишева Я.А., Галкина М.А., Сытдыков И.Х.https://creativecommons.org/licenses/by/4.0https://innoscience.ru/2500-1388/article/view/43743

This review highlights the principles of early diagnosis and treatment of patients with heterozygous familial hypercholesterolemia. Innovative and highly efficient technologies exist for prevention of the atherosclerotic process in the arterial part of the vascular system, its inhibition and elimination. They help to stabilize the patient's condition and to reduce the target organs damage. The treatment strategy, described in this review, is effective in terms of cure and pharmacoeconomics. It decreases the risk of atherosclerotic cardiovascular disease (ASCVD) and its complications in patients. The positive outcomes are the decrease of exposure to extreme level of LDL-C, reduction of the cumulative burden of disease and mortality rate, the extension of patients' life expectancy.

В обзорной статье отражены принципы ранней диагностики и лечения пациентов с семейной гетерозиготной гиперхолестеринемией. Инновационные и высокоэффективные технологии способствуют предупреждению, замедлению, остановке прогрессирования, стабилизации, а порой и регрессу развития атеросклеротического процесса в артериальном звене сосудистой системы и поражения органов-мишеней. Описанная стратегия ведения пациентов снижает риск развития атеросклеротических сердечно-сосудистых заболеваний и их осложнений, она эффективна клинически и целесообразна фармакоэкономически. Это обусловлено уменьшением экспозиции экстремального уровня ХС ЛНП, кумулятивного бремени заболевания, снижением смертности и увеличением продолжительности жизни пациентов.

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