Science and Innovations in MedicineScience and Innovations in Medicine2500-13882618-754XFSBEI of Higher Education SamSMU of Ministry of Health of the Russian Federation4737910.35693/2500-1388-2020-5-3-210-215Research ArticleFibroblasts as the subject of proliferative activity research in vitroKuzmichevaValeriya I.<p>assistant of the Chair of fundamental and clinical biochemistry with laboratory diagnostics</p>bio-sam@yandex.ruhttps://orcid.org/0000-0002-5232-1549VolovaLarisa T.<p>PhD, Professor, the Head of Biotechnology Department of IEMB, director of Samara Tissue Bank</p>bio-sam@yandex.ruhttps://orcid.org/0000-0002-8510-3118GilmiyarovaFrida N.<p>PhD, Professor, Chair of fundamental and clinical biochemistry with laboratory diagnostics</p>bio-sam@yandex.ruhttps://orcid.org/0000-0001-5992-3609BykovIlya M.<p>PhD, the Head of the Department of fundamental and clinical biochemistry</p>bio-sam@yandex.ruhttps://orcid.org/0000-0002-1787-0040AvdeevaElena V.<p>Dr. Sci. of Pharmacy, Professor, Department of pharmacognosy with botany and the basics of phytotherapy</p>bio-sam@yandex.ruhttps://orcid.org/0000-0003-3425-7157KolotievaNatalya A.<p>PhD, Associate Professor, the Chair of fundamental and clinical biochemistry with laboratory diagnostics</p>bio-sam@yandex.ruhttps://orcid.org/0000-0002-7853-6222Samara State Medical UniversityKuban State Medical University20102020532102151910202019102020Copyright © 2020, Kuzmicheva V.I., Volova L.T., Gilmiyarova F.N., Bykov I.M., Avdeeva E.V., Kolotieva N.A.2020<p>This review presents the data devoted to anatomical and functional diversity of fibroblasts, peculiarities of metabolic processes and energy exchange in these cells.</p>
<p>In particular, the changes in fibroblast proliferative activity depending on various factors are discussed. The review shows the influence of the malate dehydrogenase shuttle system on the activity of metabolic processes and the life span of fibroblasts<em>in vitro</em>. The increase of cell cultivation time<em>in vitro</em>is associated with the cytosolic isoform of this enzyme.</p>
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