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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Science and Innovations in Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Science and Innovations in Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Наука и инновации в медицине</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2500-1388</issn><issn publication-format="electronic">2618-754X</issn><publisher><publisher-name xml:lang="en">FSBEI of Higher Education SamSMU of Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">501769</article-id><article-id pub-id-type="doi">10.35693/SIM501769</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Oncology and radiotherapy</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Онкология, лучевая терапия</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Delayed reconstruction of pharyngeal and pharyngoesophageal defects in patients with malignant neoplasms of the larynx and laryngopharynx after laryngectomy</article-title><trans-title-group xml:lang="ru"><trans-title>Отсроченные реконструкции фарингеальных и арингоэзофагеальных дефектов у пациентов со злокачественными новообразованиями гортани и гортаноглотки после ларингэктомии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1765-6965</contrib-id><name-alternatives><name xml:lang="en"><surname>Kaganov</surname><given-names>Oleg I.</given-names></name><name xml:lang="ru"><surname>Каганов</surname><given-names>О. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor, the Head of the Department of <italic>Oncology</italic>; Deputy chief physician for scientific work</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор, заведующий кафедрой онкологии; заместитель главного врача по научной работе</p></bio><email>o.i.kaganov@samsmu.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4782-2912</contrib-id><name-alternatives><name xml:lang="en"><surname>Sidorenko</surname><given-names>Aleksandra O.</given-names></name><name xml:lang="ru"><surname>Сидоренко</surname><given-names>Александра Олеговна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, oncologist</p></bio><bio xml:lang="ru"><p>врач-онколог</p></bio><email>alex11bahareva@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3957-9526</contrib-id><name-alternatives><name xml:lang="en"><surname>Orlov</surname><given-names>Andrei E.</given-names></name><name xml:lang="ru"><surname>Орлов</surname><given-names>А. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Chief physician, Professor of the Department of Healthcare Service Quality in the Institute of Postgraduate Education</p></bio><bio xml:lang="ru"><p>д-р мед. наук; главный врач; профессор кафедры общественного здоровья и организации здравоохранения ИПО</p></bio><email>info@samaraonco.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2182-5429</contrib-id><name-alternatives><name xml:lang="en"><surname>Makhonin</surname><given-names>Aleksandr A.</given-names></name><name xml:lang="ru"><surname>Махонин</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine), assistant of the Department of Oncology; Head of the Oncology Department of Head and Neck Tumors</p></bio><bio xml:lang="ru"><p>канд. мед. наук, ассистент кафедры онкологии; заведующий онкологическим отделением опухоли головы, шеи</p></bio><email>makhoninAA@samaraonko.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5321-6070</contrib-id><name-alternatives><name xml:lang="en"><surname>Gabrielyan</surname><given-names>Aleksei G.</given-names></name><name xml:lang="ru"><surname>Габриелян</surname><given-names>А. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine), assistant of the Department of Dentistry of the IPE; physician maxillofacial surgeon</p></bio><bio xml:lang="ru"><p>канд. мед. наук, ассистент кафедры стоматологии ИПО; врач челюстно-лицевой хирург</p></bio><email>Gabriel_002@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Samara State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Samara Regional Clinical Oncology Center</institution></aff><aff><institution xml:lang="ru">ГБУЗ «Самарский областной клинический онкологический диспансер»</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2024-03-01" publication-format="electronic"><day>01</day><month>03</month><year>2024</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-03-10" publication-format="electronic"><day>10</day><month>03</month><year>2025</year></pub-date><volume>10</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>44</fpage><lpage>49</lpage><history><date date-type="received" iso-8601-date="2023-06-20"><day>20</day><month>06</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-08-22"><day>22</day><month>08</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Kaganov O.I., Sidorenko A.O., Orlov A.E., Makhonin A.A., Gabrielyan A.G.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Каганов О.И., Сидоренко А.О., Орлов А.Е., Махонин А.А., Габриелян А.Г.</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Kaganov O.I., Sidorenko A.O., Orlov A.E., Makhonin A.A., Gabrielyan A.G.</copyright-holder><copyright-holder xml:lang="ru">Каганов О.И., Сидоренко А.О., Орлов А.Е., Махонин А.А., Габриелян А.Г.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://innoscience.ru/2500-1388/article/view/501769">https://innoscience.ru/2500-1388/article/view/501769</self-uri><abstract xml:lang="en"><p><bold>Aim of the review </bold>– to investigate the current surgical approaches and complications of delayed reconstruction of pharyngeal and pharyngoesophageal defects in patients with malignant neoplasms of the larynx and laryngopharynx after laryngectomy using different reconstructive materials.</p> <p>The most frequent complication after delayed reconstructive surgery was anastomosis incompetence with subsequent formation of fistula and stricture. The causes of this complication in the presence of viability of reconstructive plastic material included postradiation changes, inflammatory process in the tissues in the defect area, weakened nutritional status of the patient and a number of other reasons.</p> <p>When planning delayed reconstruction of pharyngeal defects, a personalized approach is necessary in each clinical case in choosing the timing and type of plastic material.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Цель обзора</bold> – изучить существующие хирургические подходы и осложнения при отсроченной реконструкции фарингеальных и фарингоэзофагеальных дефектов у пациентов со злокачественными новообразованиями гортани и гортаноглотки после ларингэктомии с применением различного реконструктивного материала.</p> <p>Наиболее частыми осложнениями после отсроченных реконструктивных операций являются несостоятельность анастомоза с последующим формированием свища и стриктуры. К причинам возникновения данных осложнений при наличии жизнеспособности реконструктивного пластического материала можно отнести постлучевые изменения, наличие воспалительного процесса в тканях в области дефекта, ослабленный нутритивный статус пациента и ряд других причин.</p> <p>Таким образом, при планировании отсроченной реконструкции дефектов глотки в выборе сроков и вида пластического материала необходим персонифицированный подход в каждом клиническом случае.</p></trans-abstract><kwd-group xml:lang="en"><kwd>greater pectoral muscle flap</kwd><kwd>radial forearm flap</kwd><kwd>plastic material</kwd><kwd>anterolateral thigh flap</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>лоскут большой грудной мышцы</kwd><kwd>лучевой лоскут предплечья</kwd><kwd>пластический материал</kwd><kwd>переднелатеральный лоскут бедра</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Malignant neoplasms in Russia in 2021 (morbidity and mortality). 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