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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Science and Innovations in Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Science and Innovations in Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Наука и инновации в медицине</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2500-1388</issn><issn publication-format="electronic">2618-754X</issn><publisher><publisher-name xml:lang="en">FSBEI of Higher Education SamSMU of Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">59236</article-id><article-id pub-id-type="doi">10.35693/2500-1388-2021-6-2-20-24</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ENT Disorders</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Болезни уха, горла и носа</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Observation of COVID-19-associated coagulopathy in a patient of ENT hospital</article-title><trans-title-group xml:lang="ru"><trans-title>Наблюдение COVID-19-ассоциированной коагулопатии у больного оториноларингологического стационара</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1955-6423</contrib-id><name-alternatives><name xml:lang="en"><surname>Zavalko</surname><given-names>Tatyana A.</given-names></name><name xml:lang="ru"><surname>Завалко</surname><given-names>Татьяна Анатольевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Head of the Otorhinolaryngology Department, PhD, assistant of the Otorhinolaryngology Department named after academician I.B. Soldatov</p></bio><bio xml:lang="ru"><p>заведующая оториноларингологическим отделением, к.м.н., ассистент кафедры оториноларингологии им. академика И.Б. Солдатова</p></bio><email>fzavalko@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1221-5589</contrib-id><name-alternatives><name xml:lang="en"><surname>Vladimirova</surname><given-names>Tatyana Y.</given-names></name><name xml:lang="ru"><surname>Владимирова</surname><given-names>Татьяна Юльевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Associate professor, Head of the Otorhinolaryngology Department and Clinic named after academician I.B. Soldatov</p></bio><bio xml:lang="ru"><p>к.м.н., доцент, заведующая кафедрой и клиникой оториноларингологии им. академика И.Б. Солдатова</p></bio><email>vladimirovalor@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6536-8784</contrib-id><name-alternatives><name xml:lang="en"><surname>Baryshevskaya</surname><given-names>Lyudmila A.</given-names></name><name xml:lang="ru"><surname>Барышевская</surname><given-names>Людмила Андреевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Associate professor, Otorhinolaryngology Department named after academician I.B. Soldatov</p></bio><bio xml:lang="ru"><p>к.м.н., доцент, доцент кафедры оториноларингологии им. академика И.Б. Солдатова</p></bio><email>baryshevskaya.ludmila@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6458-1914</contrib-id><name-alternatives><name xml:lang="en"><surname>Fileva</surname><given-names>Lyubov V.</given-names></name><name xml:lang="ru"><surname>Филева</surname><given-names>Любовь Вадимовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>assistant of the Otorhinolaryngology Department named after academician I.B. Soldatov</p></bio><bio xml:lang="ru"><p>ассистент кафедры оториноларингологии им. академика И.Б. Солдатова</p></bio><email>s-amor@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9995-1006</contrib-id><name-alternatives><name xml:lang="en"><surname>Medvedeva</surname><given-names>Ekaterina D.</given-names></name><name xml:lang="ru"><surname>Медведева</surname><given-names>Екатерина Дмитриевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Clinical Resident of the Department of Otorhinolaryngology named after academician I.B. Soldatov</p></bio><bio xml:lang="ru"><p>ординатор кафедры оториноларингологии им. академика И.Б. Солдатова</p></bio><email>katemed96@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Samara State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Samara Clinical Hospital №8</institution></aff><aff><institution xml:lang="ru">ГБУЗ СО «Самарская городская клиническая больница №8»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-06-30" publication-format="electronic"><day>30</day><month>06</month><year>2021</year></pub-date><volume>6</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>20</fpage><lpage>24</lpage><history><date date-type="received" iso-8601-date="2021-01-25"><day>25</day><month>01</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-02-16"><day>16</day><month>02</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Zavalko T.A., Vladimirova T.Y., Baryshevskaya L.A., Fileva L.V., Medvedeva E.D.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, Завалко Т.А., Владимирова Т.Ю., Барышевская Л.А., Филева Л.В., Медведева Е.Д.</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Zavalko T.A., Vladimirova T.Y., Baryshevskaya L.A., Fileva L.V., Medvedeva E.D.</copyright-holder><copyright-holder xml:lang="ru">Завалко Т.А., Владимирова Т.Ю., Барышевская Л.А., Филева Л.В., Медведева Е.Д.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://innoscience.ru/2500-1388/article/view/59236">https://innoscience.ru/2500-1388/article/view/59236</self-uri><abstract xml:lang="en"><p>The article presents a clinical case of a patient of the otorhinolaryngology department of the Samara Clinical Hospital No. 8 who had a new coronavirus infection. Complications were manifested by primary thrombosis of the orbital veins, facial veins, followed by the spread of the process into the pterygoid plexus, veins of the nasal cavity and paranasal sinuses.</p> <p>The study analyzes the dynamics of the clinical picture and compares it with the results of the postmortem examination.</p> <p>Vascular thrombosis of the nasal cavity and paranasal sinuses during X-ray examination can manifest itself as a decrease in pneumatization of the sinuses with possible minor exudation due to ischemic changes in the mucous membrane. Thrombosis developing with underlying COVID-19-associated coagulopathy can have different initial localizations and are a formidable complication with a high mortality rate.</p> <p>Patients who have undergone COVID-19 need to control the coagulogram not only during the illness, but also during the period of convalescence and early periods after recovery.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлен клинический случай пациента оториноларингологического отделения ГБУЗ СО СГКБ №8, перенесшего новую коронавирусную инфекцию. Осложнения проявились первичным тромбозом вен глазницы, лицевых вен с последующим распространением процесса в крыловидное сплетение, вены полости носа и околоносовых пазух.</p> <p>В работе проведен анализ динамики клинической картины и сопоставление с результатами патологоанатомического исследования.</p> <p>Тромбоз сосудов полости носа и околоносовых пазух при рентгенологическом исследовании может проявляться снижением пневматизации пазух с возможной незначительной экссудацией за счет ишемических изменений слизистой оболочки. Тромбозы, развивающиеся на фоне COVID-19-ассоциированной коагулопатии, могут иметь различные начальные локализации и являются грозным осложнением с высоким уровнем летальности.</p> <p>Пациентам, перенесшим COVID-19, необходим контроль коагулограммы не только во время заболевания, но и в период реконвалесценции и ранние сроки после выздоровления.</p></trans-abstract><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>maxillary sinusitis</kwd><kwd>thrombosis</kwd><kwd>coagulopathy</kwd><kwd>paranasal sinuses</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>верхнечелюстной синусит</kwd><kwd>тромбозы</kwd><kwd>коагулопатия</kwd><kwd>околоносовые пазухи</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle. J Med Virol. 2020;92(4):401-402. doi: 10.1002/jmv.25678</mixed-citation><mixed-citation xml:lang="ru">1.Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle. J Med Virol. 2020 Apr;92(4):401-402. doi: 10.1002/jmv.25678Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle. J Med Virol. 2020 Apr;92(4):401-402. doi: 10.1002/jmv.25678</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Hui DS, E IA, Madani TA, Ntoumi F, Kock R, Dar O, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health – the latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis. 2020;91:264-6. doi: 10.1016/j.ijid.2020.01.009</mixed-citation><mixed-citation xml:lang="ru">2.Hui DS, E IA, Madani TA, Ntoumi F, Kock R, Dar O, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health – the latest 2019novel coronavirus outbreak in Wuhan, China. Int J Infect Dis 2020; 91:264–6. doi: 10.1016/j.ijid.2020.01.009</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Temporary guidelines. Prevention, diagnosis and treatment of new coronavirus infection (COVID-19). Version 8 from 03/09/20. Working group of authors. (In Russ.). [Временные методические рекомендации. Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19). Версия 8 от 03.09.20. Рабочая группа авторов].</mixed-citation><mixed-citation xml:lang="ru">3.Временные методические рекомендации. Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19). Версия 8 от 03.09.20. Рабочая группа авторов. 227c.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Whyte CS, Morrow GB, Mitchell JL, Chowdary P, Mutch NJ. Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID-19. J Thromb Haemost. 2020;18(7):1548-1555. doi: 10.1111/jth.14872</mixed-citation><mixed-citation xml:lang="ru">4.Whyte CS, Morrow GB, Mitchell JL, Chowdary P, Mutch NJ. Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID-19. J Thromb Haemost. 2020;18(7):1548-1555. doi:10.1111/jth.14872</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">Idell S, James KK, Levin EG, et al. Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest. 1989;84(2):695-705. doi: 10.1172/JCI114217</mixed-citation><mixed-citation xml:lang="ru">5.Idell S, James KK, Levin EG, et al. Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest. 1989;84(2):695-705. doi: 10.1172/JCI114217</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844-847. doi: 10.1111/jth.14768</mixed-citation><mixed-citation xml:lang="ru">6.Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844-847. doi: 10.1111/jth.14768</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Klok FA, Kruip MJHA, van der Meer NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020;191:145-147. doi: 10.1016/j.thromres.2020.04.013</mixed-citation><mixed-citation xml:lang="ru">7.Klok FA, Kruip MJHA, van der Meer NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020; 191:145-147.S0049-3848(20)30120-1. doi: 10.1016/j.thromres.2020.04.013</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">Haimei MA. Pathogenesis and Treatment Strategies of COVID-19-Related Hypercoagulant and Thrombotic Complications. Clinical and Applied Thrombosis / Hemostasis. 2020;26:1-5. doi: 10.1177/1076029620944497</mixed-citation><mixed-citation xml:lang="ru">8.Haimei MA. Pathogenesis and Treatment Strategies of COVID-19-Related Hypercoagulant and Thrombotic Complications. Clinical and AppliedThrombosis/ Hemostasis, Volume 26: 1-5, 2020. doi: 10.1177/1076029620944497</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">Spiezia L, Boscolo A, Poletto F, et al. COVID-19-related severe hypercoagulability in patients admitted to intensive care unit for acute respiratory failure. Thromb Haemost. 2020;120(6):998-1000. doi: 10.1055/s-0040-1710018</mixed-citation><mixed-citation xml:lang="ru">9.Spiezia L, Boscolo A, Poletto F, et al. COVID-19-related severe hypercoagulability in patients admitted to intensive care unit for acute respiratory failure. Thromb Haemost. 2020;120(6):998-1000. doi:10.1055/s-0040-1710018</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">Zhai Z, Li C, Chen Y, et al. Prevention and treatment of venous thromboembolism associated with coronavirus disease 2019 infection: a consensus statement before guidelines. Thromb Haemost. 2020;120(6):937-948. doi: 10.1055/s-0040-1710019</mixed-citation><mixed-citation xml:lang="ru">10. Zhai Z, Li C, Chen Y, et al. Prevention and treatment of venous thromboembolism associated with coronavirus disease 2019 infection: a consensus statement before guidelines. Thromb Haemost. 2020; 120(6):937-948. doi:10.1055/s-0040-1710019</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">Галстян Г.М. Коагулопатия при COVID-19. Пульмонология. 2020;30(5):645-657. doi: 10.18093/0869-0189-2020-30-5-645-657</mixed-citation><mixed-citation xml:lang="ru">11. Галстян Г.М. Коагулопатия при COVID-19. Пульмонология. 2020; 30 (5): 645–657</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">Lobastov KV, Schastlivtsev IV, Porembskaya OYa, et al. COVID-19-associated coagulopathy: an overview of current guidelines for diagnosis, treatment and prevention. Inpatient replacement technologies: Outpatient surgery. 2020;(3-4). (In Russ.). [Лобастов К.В., Счастливцев И.В., Порембская О.Я. и др. COVID-19-ассоциированная коагулопатия: обзор современных рекомендаций по диагностике, лечению и профилактике. Стационарозамещающие технологии: Амбулаторная хирургия. 2020;(3-4)]. doi: 10.21518/1995-1477-2020-3-4</mixed-citation><mixed-citation xml:lang="ru">doi: 10.18093/0869-0189-2020-30-5-645-657</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">Cattaneo M, Bertinato EM, Birocchi S, et al. Pulmonary embolism or pulmonary thrombosis in COVID-19? Is the recommendation to use high-dose heparin for thromboprophylaxis justified? Thromb Haemost. 2020. doi: 10.1055/s-0040-1712097</mixed-citation><mixed-citation xml:lang="ru">12. Лобастов К.В., Счастливцев И.В., Порембская О.Я., Дженина О.В., Барганджия А.Б., Цаплин С.Н. COVID-19-ассоциированная коагулопатия: обзор современных рекомендаций по диагностике, лечению и профилактике. Стационарозамещающие технологии: Амбулаторная хирургия. 2020;(3–4)</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">Harapan H, Itoh N, Yufika A. Coronavirus disease 2019 (COVID-19). A literature review. J Infect Public Health. 2020 May;13(5):667-673. doi: 10.1016/j.jiph.2020.03.019</mixed-citation><mixed-citation xml:lang="ru">doi: 10.21518/1995-1477-2020-3-4</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">Levi M, Thachil J, Iba T, Levy JH. Coagulation abnormalities and thrombosis in patients with COVID-19. Lancet Haematol. 2020;7(6):438-440. doi: 10.1016/S2352-3026(20)30145-9</mixed-citation><mixed-citation xml:lang="ru">13. Cattaneo M, Bertinato EM, Birocchi S, et al. Pulmonary embolism or pulmonary thrombosis in COVID-19? Is the recommendation to use high-dose heparin for thromboprophylaxis justified? Thromb Haemost. 2020. doi:10.1055/s-0040-1712097</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><mixed-citation>14. Harapan Harapan, Naoya Itoh, Amanda Yufika, Wira Winardi, Synat Keam, Haypheng Te, Dewi Megawati, Zinatul Hayati, Abram L Wagner. Coronavirus disease 2019 (COVID-19) A literature review J Infect Public Health, 2020 May;13(5):667-673. doi: 10.1016/j.jiph.2020.03.019</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>15. Marcel Levi, Jecko Thachil, Toshiaki Iba, and Jerrold H Levy. Coagulation abnormalities and thrombosis in patients with COVID-19. Lancet Haematol. 2020 Jun; 7(6): e438–e440. doi: 10.1016/S2352-3026(20)30145-9</mixed-citation></ref></ref-list></back></article>
