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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Science and Innovations in Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Science and Innovations in Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Наука и инновации в медицине</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2500-1388</issn><issn publication-format="electronic">2618-754X</issn><publisher><publisher-name xml:lang="en">FSBEI of Higher Education SamSMU of Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">636947</article-id><article-id pub-id-type="doi">10.35693/SIM636947</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Medical Informatics</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Медицинская информатика</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Automatic segmentation of demyelination lesions in multiple sclerosis</article-title><trans-title-group xml:lang="ru"><trans-title>Автоматическая сегментация очагов демиелинизации при рассеянном склерозе</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1709-6195</contrib-id><name-alternatives><name xml:lang="en"><surname>Zakharov</surname><given-names>Alexander V.</given-names></name><name xml:lang="ru"><surname>Захаров</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Associate professor, Head of the Neurosciences Research Institute</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент, директор НИИ нейронаук</p></bio><email>zakharov1977@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7670-6566</contrib-id><name-alternatives><name xml:lang="en"><surname>Shirolapov</surname><given-names>Igor V.</given-names></name><name xml:lang="ru"><surname>Широлапов</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Associate professor, Head of laboratory</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент, заведующий лабораторией трансляционных исследований и персонализированной медицины</p></bio><email>ishirolapov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1878-7951</contrib-id><name-alternatives><name xml:lang="en"><surname>Khivintseva</surname><given-names>Elena V.</given-names></name><name xml:lang="ru"><surname>Хивинцева</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Associate professor of the Department of Neurology and Neurosurgery</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент кафедры неврологии и нейрохирургии</p></bio><email>e.v.hivinceva@samsmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0926-8551</contrib-id><name-alternatives><name xml:lang="en"><surname>Sergeeva</surname><given-names>Mariya S.</given-names></name><name xml:lang="ru"><surname>Сергеева</surname><given-names>М. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Associate professor</p></bio><bio xml:lang="ru"><p>канд. биол. наук, доцент, ведущий специалист НИИ нейронаук</p></bio><email>m.s.sergeeva@samsmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3522-6803</contrib-id><name-alternatives><name xml:lang="en"><surname>Romanchuk</surname><given-names>Natalya P.</given-names></name><name xml:lang="ru"><surname>Романчук</surname><given-names>Н. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, MD, Associate professor, Head of the laboratory of neuromorphic systems, research institute of neurosciences</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент, заведующий лабораторией нейроморфных систем НИИ нейронаук</p></bio><email>n.p.romanchuk@samsmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-7902-6964</contrib-id><name-alternatives><name xml:lang="en"><surname>Dedyk</surname><given-names>Dmitry A.</given-names></name><name xml:lang="ru"><surname>Дедык</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>engineer of the advanced engineering school</p></bio><bio xml:lang="ru"><p>инженер передовой инженерной школы</p></bio><email>d.a.dedyk@samsmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-6516-8216</contrib-id><name-alternatives><name xml:lang="en"><surname>Melnikova</surname><given-names>Darya D.</given-names></name><name xml:lang="ru"><surname>Мельникова</surname><given-names>Д. Д.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>engineer of the advanced engineering school</p></bio><bio xml:lang="ru"><p>инженер передовой инженерной школы</p></bio><email>Daha442242@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-0292-930X</contrib-id><name-alternatives><name xml:lang="en"><surname>Andreev</surname><given-names>Arseniy M.</given-names></name><name xml:lang="ru"><surname>Андреев</surname><given-names>А. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>engineer of the advanced engineering school</p></bio><bio xml:lang="ru"><p>инженер передовой инженерной школы</p></bio><email>2001qwert2001@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-4429-7554</contrib-id><name-alternatives><name xml:lang="en"><surname>Mavletova</surname><given-names>Alexandra I.</given-names></name><name xml:lang="ru"><surname>Мавлетова</surname><given-names>А. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>engineer of the advanced engineering school</p></bio><bio xml:lang="ru"><p>инженер передовой инженерной школы</p></bio><email>alexamavletova@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-5925-6426</contrib-id><name-alternatives><name xml:lang="en"><surname>Shchepetov</surname><given-names>Anton O.</given-names></name><name xml:lang="ru"><surname>Щепетов</surname><given-names>А. О.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>engineer of the advanced engineering school</p></bio><bio xml:lang="ru"><p>инженер передовой инженерной школы</p></bio><email>antonshepetov1@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6091-1880</contrib-id><name-alternatives><name xml:lang="en"><surname>Hemanth</surname><given-names>Jude</given-names></name><name xml:lang="ru"><surname>Hemanth</surname><given-names>Jude</given-names></name></name-alternatives><address><country country="IN">India</country></address><bio xml:lang="en"><p>PhD, Professor</p></bio><bio xml:lang="ru"><p>профессор</p></bio><email>judehemanth@karunya.edu</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Samara State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Karunya Institute of Technology and Sciences</institution></aff><aff><institution xml:lang="ru">Институт технологий и наук Карунья</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2024-11-26" publication-format="electronic"><day>26</day><month>11</month><year>2024</year></pub-date><pub-date date-type="pub" iso-8601-date="2024-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2024</year></pub-date><volume>9</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>284</fpage><lpage>290</lpage><history><date date-type="received" iso-8601-date="2024-10-12"><day>12</day><month>10</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-10-22"><day>22</day><month>10</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Zakharov A.V., Shirolapov I.V., Khivintseva E.V., Sergeeva M.S., Romanchuk N.P., Dedyk D.A., Melnikova D.D., Andreev A.M., Mavletova A.I., Shchepetov A.O., Hemanth J.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Захаров А.В., Широлапов И.В., Хивинцева Е.В., Сергеева М.С., Романчук Н.П., Дедык Д.А., Мельникова Д.Д., Андреев А.М., Мавлетова А.И., Щепетов А.О., Hemanth J.</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Zakharov A.V., Shirolapov I.V., Khivintseva E.V., Sergeeva M.S., Romanchuk N.P., Dedyk D.A., Melnikova D.D., Andreev A.M., Mavletova A.I., Shchepetov A.O., Hemanth J.</copyright-holder><copyright-holder xml:lang="ru">Захаров А.В., Широлапов И.В., Хивинцева Е.В., Сергеева М.С., Романчук Н.П., Дедык Д.А., Мельникова Д.Д., Андреев А.М., Мавлетова А.И., Щепетов А.О., Hemanth J.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://innoscience.ru/2500-1388/article/view/636947">https://innoscience.ru/2500-1388/article/view/636947</self-uri><abstract xml:lang="en"><p><bold>Aim</bold> – to evaluate the effectiveness of the YOLOv8 algorithm for automatic segmentation of demyelination lesions in various locations in patients with multiple sclerosis.</p> <p><bold>Material and methods.</bold> The study included 120 patients with a clinically confirmed diagnosis of multiple sclerosis who underwent contrast-enhanced MRI. The MRI data from patients with different types of disease progression were analyzed. T1-weighted, T2-weighted, and FLAIR sequences were used for the analysis. The YOLOv8 algorithm was adapted for medical imaging and trained on manually annotated MRI scans. Model performance was evaluated using precision, recall, and F1-Score metrics.</p> <p><bold>Results. </bold>The YOLOv8 model demonstrated high segmentation performance with a precision of 0.79, recall of 00.73, and F1-Score of 0.65. The model effectively identified demyelination lesions in various locations typical for multiple sclerosis. However, there remains a need to improve recall to minimize the missed lesions. Testing on independent data confirmed the stability of the results of the model.</p> <p><bold>Conclusion. </bold>The YOLOv8 algorithm shows significant potential for automatic segmentation of demyelination lesions in multiple sclerosis patients. This method could be successfully implemented in clinical practice, enabling faster diagnosis and improved monitoring of disease progression. Further optimization of the model, through data augmentation techniques and hybrid architectures, may enhance both segmentation accuracy and recall.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Цель</bold> – оценить эффективность использования алгоритма YOLOv8 для автоматической сегментации очагов демиелинизации различной локализации у пациентов с рассеянным склерозом.</p> <p><bold>Материал и методы. </bold>В исследование включены 120 пациентов с клинически достоверным диагнозом «рассеянный склероз», которым была проведена МРТ с контрастированием. Были проанализированы МРТ пациентов с различным типом течения заболевания. Для анализа использовались T1-, T2-взвешенные и FLAIR последовательности. Алгоритм YOLOv8 был адаптирован для медицинских данных и обучен на размеченных вручную МРТ-снимках. Оценка производительности модели проводилась с использованием метрик точности (Precision), полноты (Recall) и F1-мера.</p> <p><bold>Результаты. </bold>Модель YOLOv8 показала высокие результаты сегментации: точность – 0,79, полнота – 0,73, F1 мера – 0,61. Модель эффективно идентифицировала очаги демиелинизации различной локализации, типичной для рассеянного склероза. Остается необходимость в повышении полноты для минимизации пропуска поражений. Тестирование на независимых данных подтвердило стабильность результатов модели.</p> <p><bold>Выводы. </bold>Алгоритм YOLOv8 демонстрирует высокий потенциал для автоматической сегментации очагов демиелинизации у пациентов с рассеянным склерозом. Данная методика может быть успешно внедрена в клиническую практику, что позволит ускорить диагностику и улучшить контроль за прогрессированием заболевания. Для дальнейшего повышения точности и полноты сегментации возможна оптимизация модели через использование методов усиления данных и гибридных архитектур.</p></trans-abstract><kwd-group xml:lang="en"><kwd>magnetic resonance imaging</kwd><kwd>multiple sclerosis</kwd><kwd>segmentation</kwd><kwd>deep learning</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>магнитно-резонансная томография</kwd><kwd>рассеянный склероз</kwd><kwd>сегментация</kwd><kwd>глубокое обучение</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Jakimovski D, Bittner S, Zivadinov R, et al. Multiple sclerosis. The Lancet. 2024;403(10422):183-202. DOI: https://doi.org/10.1016/S0140-6736(23)01473-3</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Kaisey M, Solomon AJ. Multiple Sclerosis Diagnostic Delay and Misdiagnosis. Neurologic Clinics. 2024;42(1):1-13. 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