Science and Innovations in MedicineScience and Innovations in Medicine2500-13882618-754XFSBEI of Higher Education SamSMU of Ministry of Health of the Russian Federation6671410.35693/2500-1388-2021-6-3-63-68Research ArticlePlatelet-rich plasma in the treatment of chronic inflammatory diseases of lower extremitiesGilevichIrina V.<p>PhD, Head of the Laboratory for development and study of new treatment technologies, Assistant of Oncology Department with a course of thoracic surgery</p>giliv@list.ruhttps://orcid.org/0000-0002-9766-1811ShubrovErik N.<p>surgeon of the Department of purulent surgery</p>erik.nalchanin@yandex.ruhttps://orcid.org/0000-0002-0864-3938ChuchvarevRoman V.<p>surgeon of the Department of purulent surgery</p>rchuchvaryov@mail.ruKolomiytcevaElena A.<p>biologist of the Laboratory for development and study of new treatment technologies</p>kmc78@mail.ruhttps://orcid.org/0000-0002-7773-9159TriandafilovKonstantin V.<p>Head of the Department of purulent surgery</p>gnhirkkbo@mail.ruSotnichenkoAleksandr S.<p>PhD, Head of the Laboratory of basic research in the field of regenerative medicine</p>alex24.88@mail.ruhttps://orcid.org/0000-0001-7322-0459MelkonyanKarina I.<p>PhD, Head of the Central research laboratory, Associate professor of Fundamental and clinical biochemistry Department</p>kimelkonian@gmail.comhttps://orcid.org/0000-0003-2451-6813Research Institute – S. V. Ochapovsky Regional Clinic Hospital No.1Kuban State Medical University300920216363682904202108062021Copyright © 2021, Gilevich I.V., Shubrov E.N., Chuchvarev R.V., Kolomiytceva E.A., Triandafilov K.V., Sotnichenko A.S., Melkonyan K.I.2021<p><strong>Objectives </strong> to evaluate the effectivenes of platelet-rich plasma preparations in the treatment of chronic inflammatory diseases of lower extremities.</p>
<p><strong>Material and methods.</strong> The study involved patients hospitalized in the Research Institute S. V. Ochapovsky Regional Clinic Hospital No.1, Krasnodar, with trophic ulcers and chronic osteomyelitis. The patients received injections of platelet-rich plasma as platelet lysate and/or platelet gel.</p>
<p><strong>Results.</strong> The study involved 19 patients with trophic ulcers of the lower extremities with a duration of more than 2 months. Previously, the patients had underwent therapy without effect. In all cases, the patients received a complex of therapeutic measures, including debridement, dressing, conservative treatment, physiotherapy, antibiotic therapy. In the presence of large ulcers, 8 patients underwent autodermoplasty with complete engraftment. It has been noted that during platelet-rich plasma use the average healing time was 6-7 weeks.</p>
<p>Four patients were observed with chronic osteomyelitis. During operation, the bone cavity was filled with platelet gel. The postoperative period was uneventful in all cases. The maximum observation period was 1.5 years. No recurrence of osteomyelitis was detected.</p>
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