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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Science and Innovations in Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Science and Innovations in Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Наука и инновации в медицине</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2500-1388</issn><issn publication-format="electronic">2618-754X</issn><publisher><publisher-name xml:lang="en">FSBEI of Higher Education SamSMU of Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">75512</article-id><article-id pub-id-type="doi">10.35693/2500-1388-2021-6-2-43-47</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Cardiology</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Кардиология</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Laboratory and instrumental indicators associated with decreased left ventricle ejection fraction in patients with chronic heart failure</article-title><trans-title-group xml:lang="ru"><trans-title>Лабораторные и инструментальные показатели, ассоциированные со снижением фракции выброса левого желудочка у пациентов с хронической сердечной недостаточностью</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5673-7958</contrib-id><name-alternatives><name xml:lang="en"><surname>Aidumova</surname><given-names>Olesya Yu.</given-names></name><name xml:lang="ru"><surname>Айдумова</surname><given-names>Олеся Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>cardiologist, senior laboratory assistant of the Chair of Introduction to internal medicine</p></bio><bio xml:lang="ru"><p>врач-кардиолог, старший лаборант кафедры пропедевтической терапии</p></bio><email>volga.rassvet@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3996-4689</contrib-id><name-alternatives><name xml:lang="en"><surname>Rubanenko</surname><given-names>Anatolii O.</given-names></name><name xml:lang="ru"><surname>Рубаненко</surname><given-names>Анатолий О.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Associate professor, Chair of Introduction to internal medicine</p></bio><bio xml:lang="ru"><p>к.м.н., доцент кафедры пропедевтической терапии</p></bio><email>a.o.rubanenko@samsmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8763-9629</contrib-id><name-alternatives><name xml:lang="en"><surname>Kompanets</surname><given-names>Natalya V.</given-names></name><name xml:lang="ru"><surname>Компанец</surname><given-names>Наталья В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, assistant Professor, Chair of Introduction to internal medicine</p></bio><bio xml:lang="ru"><p>к.м.н., доцент, ассистент кафедры пропедевтической терапии</p></bio><email>rogdestvenskaja@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0387-8356</contrib-id><name-alternatives><name xml:lang="en"><surname>Shchukin</surname><given-names>Yurii V.</given-names></name><name xml:lang="ru"><surname>Щукин</surname><given-names>Юрий В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Professor, Head of the Chair of Introduction to internal medicine</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, заведующий кафедрой пропедевтической терапии</p></bio><email>yu.v.schukin@samsmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Samara State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-06-30" publication-format="electronic"><day>30</day><month>06</month><year>2021</year></pub-date><volume>6</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>43</fpage><lpage>47</lpage><history><date date-type="received" iso-8601-date="2021-07-03"><day>03</day><month>07</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-07-03"><day>03</day><month>07</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Aidumova O.Y., Rubanenko A.O., Kompanets N.V., Shchukin Y.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, Айдумова О.Ю., Рубаненко А.О., Компанец Н.В., Щукин Ю.В.</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Aidumova O.Y., Rubanenko A.O., Kompanets N.V., Shchukin Y.V.</copyright-holder><copyright-holder xml:lang="ru">Айдумова О.Ю., Рубаненко А.О., Компанец Н.В., Щукин Ю.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://innoscience.ru/2500-1388/article/view/75512">https://innoscience.ru/2500-1388/article/view/75512</self-uri><abstract xml:lang="en"><p><bold>Objectives</bold> – to evaluate laboratory and instrumental indicators, associated with decreased left ventricle ejection fraction in patients with heart failure of ischemic etiology.</p> <p><bold>Material and methods.</bold> The observational study included 71 patient with coronary heart disease and chronic heart failure (CHF). All patients underwent the testing on the following parameters: uric acid concentration, C-reactive protein (hs-CRP), NT-proBNP, ST2 and cystatin C tests, glomerular filtration rate. Instrumental examination included transthoracic echocardiography and 6-minute walk test.</p> <p><bold>Results. </bold>The study revealed several indicators, associated with decreased left ventricle ejection fraction less than 50% in patients with CHF: NT-proBNP level &gt;822.2 pg/ml, ST2 &gt;38.61 ng/l, uric acid &gt; 419.9 mmol/l, hs-CRP &gt; 2.54 mg/l, end diastolic volume index &gt; 73.68 ml/m<sup>2</sup>, left ventricular mass index &gt; 127 g/m<sup>2</sup>, left ventricular contractility index &gt; 1.75, pulmonary artery pressure &gt; 29 mm Hg. and vena cava inferior diameter &gt; 20 mm.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Цель</bold> – выявить лабораторные и инструментальные показатели, ассоциированные с фракцией выброса левого желудочка у пациентов с хронической сердечной недостаточностью ишемической этиологии.</p> <p><bold>Материал и методы. </bold>Проведено одномоментное обсервационное исследование, включившее 71 пациента с ишемической болезнью сердца и ХСН. Всем пациентам проводилось определение концентрации мочевой кислоты и С-реактивного белка (СРБ), NT-proBNP, ST2, цистатина С, а также скорости клубочковой фильтрации. Всем были выполнены эхокардиография и тест 6-минутной ходьбы.</p> <p><bold>Результаты и заключение.</bold> Показателями, ассоциированными со снижением ФВ ЛЖ&lt;50%, у пациентов с ХСН являются уровень NT-proBNP&gt;822,2 пг/мл, ST2&gt;38,61 нг/мл, мочевой кислоты&gt;419,9 ммоль/л, вчСРБ&gt;2,54 мг/л, КДО\м<sup>2</sup>&gt;73,68 мл/м<sup>2</sup>,ИММЛЖ&gt;127 г/м<sup>2</sup>, ИНЛСЛЖ&gt;1,75, давление в легочной артерии&gt;29 мм рт. ст. и диаметр НПВ &gt;20 мм.</p></trans-abstract><kwd-group xml:lang="en"><kwd>chronic heart failure</kwd><kwd>biomarkers</kwd><kwd>NT-proBNP</kwd><kwd>uric acid</kwd><kwd>C-reactive protein</kwd><kwd>left ventricular ejection fraction</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>хроническая сердечная недостаточность</kwd><kwd>биомаркеры</kwd><kwd>NT-proBNP</kwd><kwd>мочевая кислота</kwd><kwd>С-реактивный белок</kwd><kwd>фракция выброса левого желудочка</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Oshchepkova EV, Lazareva NV, Satlykova DF, Tereshchenko SN. 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