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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Science and Innovations in Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Science and Innovations in Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Наука и инновации в медицине</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2500-1388</issn><issn publication-format="electronic">2618-754X</issn><publisher><publisher-name xml:lang="en">FSBEI of Higher Education SamSMU of Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">96480</article-id><article-id pub-id-type="doi">10.35693/2500-1388-2022-7-2-85-88</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Infectious diseases</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Инфекционные болезни</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Results of cytological examination of bone marrow aspirates in patients with HIV infection and cytopenia in correlation with viral load</article-title><trans-title-group xml:lang="ru"><trans-title>Результаты цитологического исследования аспиратов костного мозга у пациентов с ВИЧ-инфекцией и цитопенией в зависимости от уровня вирусной нагрузки</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8016-1039</contrib-id><name-alternatives><name xml:lang="en"><surname>Kalashnikova</surname><given-names>Darya V.</given-names></name><name xml:lang="ru"><surname>Калашникова</surname><given-names>Дарья Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Assistant of the Department of Hospital therapy, endocrinology, hematologist, Department of Hematology and Chemotherapy</p></bio><bio xml:lang="ru"><p>ассистент кафедры госпитальной терапии, эндокринологии, врач-гематолог отделения гематологии и химиотерапии</p></bio><email>dashenkabar@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6196-7256</contrib-id><name-alternatives><name xml:lang="en"><surname>Mordyk</surname><given-names>Anna V.</given-names></name><name xml:lang="ru"><surname>Мордык</surname><given-names>Анна Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Professor, Head of the Department of Phthisiology, phthisiosurgery and infectious diseases, phthisiatrician, pulmonologist</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор, заведующая кафедрой фтизиатрии, фтизиохирургии и инфекционных болезней, врач-фтизиатр, врач-пульмонолог</p></bio><email>amordik@mail.ru</email><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0495-3645</contrib-id><name-alternatives><name xml:lang="en"><surname>Puzyreva</surname><given-names>Larisa V.</given-names></name><name xml:lang="ru"><surname>Пузырева</surname><given-names>Лариса Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Associate professor of the Department of Phthisiology, phthisiosurgery and infectious diseases, phthisiatrician</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент кафедры фтизиатрии, пульмонологии и инфекционных болезней, врач-фтизиатр</p></bio><email>puzirevalv@mail.ru</email><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Omsk State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Regional Clinical Hospital</institution></aff><aff><institution xml:lang="ru">БУЗОО «Областная клиническая больница»</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Omsk State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Clinical Tuberculosis Dispensary No.4</institution></aff><aff><institution xml:lang="ru">БУЗОО «Клинический противотуберкулезный диспансер №4»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-04-29" publication-format="electronic"><day>29</day><month>04</month><year>2022</year></pub-date><volume>7</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>85</fpage><lpage>88</lpage><history><date date-type="received" iso-8601-date="2022-01-15"><day>15</day><month>01</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-02-01"><day>01</day><month>02</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Kalashnikova D.V., Mordyk A.V., Puzyreva L.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Калашникова Д.В., Мордык А.В., Пузырева Л.В.</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Kalashnikova D.V., Mordyk A.V., Puzyreva L.V.</copyright-holder><copyright-holder xml:lang="ru">Калашникова Д.В., Мордык А.В., Пузырева Л.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://innoscience.ru/2500-1388/article/view/96480">https://innoscience.ru/2500-1388/article/view/96480</self-uri><abstract xml:lang="en"><p><bold>Aim</bold> – determination of specific changes in the bone marrow in patients with HIV infection and cytopenia, depending on the viral load.</p> <p><bold>Material and methods.</bold> We analysed myelograms of patients with HIV infection and cytopenia. All patients had bicytopenia or pancytopenia in the hemogram.</p> <p><bold>Results.</bold> In patients with a viral load over 100 001 copies/ml, the hypocellularity of each of the hematopoietic cell line was significantly more often observed, hypercellularity was recorded only in the myelograms of patients with a viral load of less than 100 001 copies/ml. When assessing the signs of myelodysplasia in the bone marrow, changes in the megakaryocyte lineage (the formation of naked cells, dysmegakaryocytopoiesis) were typical for patients with a viral load of less than 10 000 copies/ml. Signs of dysplasia of the granulocytic lineage are more often determined in patients with a viral load of more than 100 001 copies/ml.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Цель</bold> – определение специфических изменений в костном мозге у пациентов с ВИЧ-инфекцией и цитопенией в зависимости от вирусной нагрузки.</p> <p><bold>Материал и методы.</bold> Выполнен анализ миелограмм у пациентов с ВИЧ-инфекцией и цитопенией. У всех пациентов в гемограмме имелась двух- или трехростковая цитопения.</p> <p><bold>Результаты.</bold> У пациентов с уровнем вирусной нагрузки выше 100 001 копий/мл достоверно чаще отмечалась гипоклеточность каждого из ростков кроветворения, гиперклеточность зарегистрирована только в миелограммах пациентов с уровнем вирусной нагрузки менее 100 001 клеток/мл. При оценке признаков миелодисплазии в костном мозге изменения мегакарицитарного ростка (образование голоядерных клеток, дизмегакариоцитопоэз) характерны для пациентов с уровнем вирусной нагрузки менее 10 000 копий/мл. Признаки дисплазии гранулоцитарного ростка чаще определяются у пациентов с уровнем вирусной нагрузки более 100 001 копий/мл.</p></trans-abstract><kwd-group xml:lang="en"><kwd>cytopenia</kwd><kwd>HIV infection</kwd><kwd>viral load</kwd><kwd>myelodysplasia</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>цитопения</kwd><kwd>ВИЧ-инфекция</kwd><kwd>вирусная нагрузка</kwd><kwd>миелодисплазия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>WHO. Global Health Sector Strategies for HIV/AIDS, Viral Hepatitis, Sexually Transmitted Infections (STIs). (In Russ.). [Всемирная организация здравоохранения. Женева Стратегии по борьбе с ИППП, ВИЧ и вирусным гепатитом]. URL: https://apps.who.int/gb/ebwha/pdf_files/WHA69/A69_31-ru.pdf?ua=1&amp;ua=1</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Zhu Q, Fang P, Zhao Y. How about the quality and recommendation on prevention, diagnosis, and treatment of HIV/AIDS guidelines developed by WHO. 2020;99(52):e23638. doi: 10.1097/ MD.0000000000023638</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Buskin SE. Sullivan PS. Anemia and its treatment and outcomes in persons infected with human immunodeficiency virus. Transfusion. 2004;44(6):826–832. doi: 10.1111/j.1537-2995.2004.03359.x</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Marchionatti A, Parisi MM. Anemia and thrombocytopenia in people living with HIV/AIDS: a narrative literature review. Int Health. 2021;13(1):98–109. doi: 10.1093/inthealth/ihaa036</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Bharuthram N, Feldman C. The diagnostic utility of bone marrow examination in an infectious disease ward. South Afr J HIV Med. 2019;20(1). doi: 10.4102/sajhivmed.v20i1.974</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Bagnara GP, Zauli G, Giovannini M. Early loss of circulating hemopoietic progenitors in HIV-1-infected subjects. Experimental hematology. 1990;18(5):426–430.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Balea M. Hematologic manifestations of infection with the human immunodeficiency virus. Romanian journal of internal medicine. 1994;32(2):87–118.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Tripathi AK, Misra R, Kalra P. Bone marrow abnormalities in HIV disease. The Journal of the Association of Physicians of India. 2005;53:705–710.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Dhurve SA, Dhurve AS. Bone Marrow Abnormalities in HIV Disease. Mediterranean journal of hematology and infectious diseases. 2013;5(1):e2013033. doi: 10.4084/MJHID.2013.033</mixed-citation></ref></ref-list></back></article>
