Experimental and Theoretical Investigation of Inclusion Complexes of β-Cyclodextrin with Fingolimod

A. A. Garibyan; Гарибян А. А.; E. S. Delyagina; Делягина Е. С.; M. L. Antipova; Антипова М. Л.; E. G. Odintsova; Одинцова Е. Г.; V. E. Petrenko; Петренко В. Е.; I. V. Terekhova; Терехова И. В.

doi:10.31857/S0044453723030135

Experimental and Theoretical Investigation of Inclusion Complexes of β-Cyclodextrin with Fingolimod

Authors: Garibyan A.A.¹, Delyagina E.S.¹^,2, Antipova M.L.¹, Odintsova E.G.¹, Petrenko V.E.¹, Terekhova I.V.¹
Affiliations:
1. G.A. Krestov Institute of Chemistry of Solutions, Russian Academy of Sciences
2. Ivanovo State University
Issue: Vol 97, No 3 (2023)
Pages: 378-385
Section: ФИЗИЧЕСКАЯ ХИМИЯ РАСТВОРОВ
Submitted: 27.02.2025
Published: 01.03.2023
URL: https://innoscience.ru/0044-4537/article/view/668797
DOI: https://doi.org/10.31857/S0044453723030135
EDN: https://elibrary.ru/DXRADY
ID: 668797

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Abstract
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Abstract

The solubilizing effect of β-cyclodextrin on fingolimod, a new generation immunosuppressant, is studied for the first time. A possible 20× increase in the solubility of fingolimod due to the penetration of the hydrophobic fragment of the drug molecule into the macrocyclic cavity of the cyclodextrin is shown. Data driven 1H NMR spectroscopy and computer modeling suggest the configuration of the resulting inclusion complexes. The constant of the complex’s stability and its energy of complexation are calculated, and the formation of hydrogen bonds between fingolimod and β-cyclodextrin is considered.

Keywords

cyclodextrin, fingolimod, complexation, solubilization

References

Salem H., Abo Elsoud F.A., Heshmat D. // Spectrochim. Acta. A: Mol. Biomol. Spectrosc. 2021. V. 250. P. 119331. https://doi.org/10.1016/j.saa.2020.119331
Jaafar N., Zeineddine M., Massouh J. et al. // Mult. Scler. Relat. 2019. V. 36. P. 101437. https://doi.org/10.1016/j.msard.2019.101437
Strader C.R., Pearce C.J., Orberlies N.H. // J. Nat. Prod. 2011. V. 74. № 4. P. 900. https:// doi.org/https://doi.org/10.1021/np2000528
Al-Izki S., Pryce G., Jackson S.J. et al. // Mult. Scler. J. 2011. V. 17. № 8. P. 939. https://doi.org/10.1177/1352458511400476
Pelletier D., Hafler M.D., Hafler D.A. // N. Engl. J. Med. 2012. V. 366. P. 339. https://doi.org/10.1056/NEJMct1101691
Aytan N., Choi J.-K., Carreras I. // Sci. Rep. 2016. V. 6. № 1. P. 24939. https://doi.org/10.1038/srep24939
Nasser A. // J. Basic. Clin. Physiol. Pharmacol. 2019. V. 30. № 5. P. 31469655. https://doi.org/10.1515/jbcpp-2019-0063
Medeiros da Silva M., Odebrecht de Souza R., Gonçalves M.V.M. // J. Neuroimmunol. 2022. V. 2. P. 100071. https://doi.org/10.1016/j.nerep.2022.100071
Gomez-Mayordomo V., Montero-Escribano P., Matías-Guiu J.A. et al. // J. Med. Virol. 2020. V. 93. № 1. P. 546. https://doi.org/10.1002/jmv.26279
Mona J., Kuo C.-J., Perevedentseva E. et al. // Diam. Relat. Mater. 2013. V. 39. P. 73. https://doi.org/10.1016/j.diamond.2013.08.001
Center for drug Evaluation and Research. 2010. https://www.accessdata.fda.gov/drugsatfda_docs/nda/ 2010/022527orig1s000clinpharmr.pdf
Tamakuwala M., Stagni G. // AAPS Pharm. Sci. Tech. 2016. V. 17. P. 907. https://doi.org/10.1208/s12249-015-0415-9
Ward M.D., Jones D.E., Goldman M.D. // Expert Opin. Drug Saf. 2014. V. 13. P. 989. https://doi.org/10.1517/14740338.2014.920820
Miranda R.R., Ferreira N.N., de Souza E.E. et al. // ACS Appl. Bio Mater. 2022. V. 5. P. 3371. https://doi.org/10.1021/acsabm.2c00349
Zeraatpisheh Z., Mirzaei E., Nami M. et al. // Eur. J. Neurosci. 2021. V. 54. № 4. P. 5620. https://doi.org/10.1111/ejn.15391
Shirmard L.R., Ghofrani M., Javan N.B. et al. // Drug Dev. Ind. Pharm. 2020. V. 46. № 2. P. 318. https://doi.org/10.1080/03639045.2020.1721524
Shahsavari S., Shirmard L.R., Amini M. et al. // J. Pharm. Sci. 2016. V. 106. P. 176. https://doi.org/10.1016/j.xphs.2016.07.026
Javan N.B., Shirmard L.R., Omid N.J. et al. // J. Microencapsul. 2016. V. 33. № 5. P. 1. https://doi.org/10.3109/10837450.2015.1108982
Zou X., Jiang Z., Li L. et al. // Artif. Cells Nanomed. Biotechnol. 2021. V. 49. № 1. P. 83. https://doi.org/10.1080/21691401.2021.1871620
Jacob S., Nair A.B. // Drug Dev. Res. 2018. V. 79. № 5. P. 201. https://doi.org/10.1002/ddr.21452
Terekhova I., Kritskiy I., Agafonov M. et al. // Int. J. Mol. Sci. 2020. V. 21. № 23. P. 9102. https://doi.org/10.3390/ijms21239102
Garibyan A., Delyagina E., Agafonov M. et al. // J. Mol. Liq. 2022. V. 360 P. 119548. https://doi.org/10.1016/j.molliq.2022.119548
Saokham P., Muankaew C., Jansook P. et al. // Molecules. 2018. V. 23. № 5. P. 1161. https://doi.org/10.3390/molecules23051161
dos Passos Menezes P., de Araújo Andrade T., Frank L.A. et al. // Int. J. Pharm. 2019. V. 559. P. 312. https://doi.org/10.1016/j.ijpharm.2019.01.041
Job P. // Annual Chemistry. 1928. V. 9. P. 113.
Becke A.D. // Phys. Rev. A. 1988. V. 38. P. 3098. https://doi.org/10.1103/PhysRevA.38.3098
Lee C., Yang W., Parr R.G. // Phys. Rev. B. 1988. V. 37. P. 785. https://doi.org/10.1103/PhysRevB.37.785
Frisch M.J., Trucks G.W., Schlegel H.B. et al.// Wallingford, CT, USA, 2016
Morris G.M., Huey R., Lindstrom W. et al. // J. Comp. Chem. 2009. V. 16. P. 2785. https://doi.org/10.1002/jcc.21256
GROMACS 2019.6. https://manual.gromacs.org/documentation/2019.6.
Nose S. // Mol. Phys. 1984. V. 52. P. 255. https://doi.org/10.1080/00268978400101201
Hoover W.G. // Phys. Rev. A. 1985. V. 31. P. 1695. https://doi.org/10.1103/PhysRevA.31.1695
Allen M.P., Tildesley D.J. // Computer Simulation of Liquids, Clarendon Press, London, 1987.
Darden T., York D., Pedersen L. // J. Chem. Phys. 1993. V. 98. P. 10089.
Essmann M.U., Perera L., Berkowitz M.L. et al. // J. Chem. Phys. 1995. V. 103. P. 8577. https://doi.org/10.1063/1.470117
Hess M.B., Bekker H., Berendsen H.J.C. et al. // J. Comput. 1997. V. 18. № 12. P. 1463. https://doi.org/10.1002/(SICI)1096-987X(199709)18:12%3C1463::AID-JCC4%3E3.0.CO;2-H
Jorgensen W.L., Tirado-Rives J. // PNAS. 2005. V. 102. P. 6665. https://doi.org/10.1073/pnas.0408037102
Dodda L.S., Vilseck J.Z., Tirado-Rives J. et al. // J. Phys. Chem. B. 2017. V. 121. P. 3864. https://doi.org/10.1021/acs.jpcb.7b00272
Dodda L.S., de Vaca I.C., Tirado-Rives J. et al. // Nucleic Acids Res. 2017. V. 45. Web Server issue W331. https://doi.org/10.1093/nar/gkx312
Jorgensen W.L., Maxwell D.S., Tirado-Rives J. // J. Am. Chem. Soc. 1996. V. 118. P. 11225. https://doi.org/10.1021/ja9621760
Humphrey W., Dalke A., Schulten K. // J. Mol. Graph. 1996. V. 14. P. 33. https://doi.org/10.1016/0263-7855(96)00018-5
Higuchi T., Connors K. // Adv. Anal. Chem. Instrum. 1964. V. 4. P. 117.
Saokham P., Muankaew C., Jansook P. et al. // Molecules. 2018. V. 23. № 5. P. 1161. https://doi.org/10.3390/molecules23051161
Prajapati M., Loftsson T. // J. Drug Deliv. Sci. Technol. 2022. V. 69. P. 103106. https://doi.org/10.1016/j.jddst.2022.103106
Szejtli J. // Chem. Rev. 1998. V. 98. P. 1743. https://doi.org/10.1021/cr970022c
Jacob S., Nair A.B. // Drug Dev. Res. 2018. V. 79. P. 201. https://doi.org/10.1002/ddr.21452