Formation of polymolecular associates of short-chain peptides with copper ions under electrospray ionization conditions

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The ionization processes of short-chain peptides in the presence of cationizing agents – ​metal salts – ​have been studied. The electrospray ionization method with mass spectrometric detection was used in this work. The mass spectrometric study demonstrated the ability of peptides to form cluster compounds with transition metal ions such as copper. It was shown that up to 2–4 peptide molecules are associated around one charged metal center. A hypothesis on the mechanism of formation of these clusters is proposed in this work, which is confirmed by experimental data.

作者简介

E. Kuznetsova

Federal State Budgetary Institution of Science A. N. Frumkin Institute of Physical Chemistry and Electrochemistry

Email: eskuznetsova8@yandex.ru
Moscow, Russia

I. Pytsky

Federal State Budgetary Institution of Science A. N. Frumkin Institute of Physical Chemistry and Electrochemistry

Moscow, Russia

A. Buryak

Federal State Budgetary Institution of Science A. N. Frumkin Institute of Physical Chemistry and Electrochemistry

Moscow, Russia

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