Determination of the Stability Constants of Supramolecular Complexes of Ester Derivatives of Betulin with Randomly Methylated β-Cyclodextrin by Affinity Capillary Electrophoresis

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Using affinity capillary electrophoresis, the stability constants of inclusion complexes of a number of betulin ester derivatives with randomly methylated β-cyclodextrin in 0.0100 M sodium tetraborate (pH 9.18, ionic strength 0.0200 M) at 25°С were determined for the first time. The decimal logarithms of the stability constants of 1 : 1 complexes of betulin 3,28-diphthalate, betulin 3,28-disulfate, and betulin 3,28-disuccinate in a 95% confidence interval were 4.64 ± 0.05, 4.78 ± 0.02, and 4.94 ± 0.02, respectively. The logarithms of the stability constants of 1 : 2 complexes of betulin 3,28-diphthalate and betulin 3,28-disulfate were 7.91 (6.66–8.19) and 8.02 (7.63–8.23), respectively. It was determined that betulin 3,28-disuccinate forms only 1 : 1 complex. The obtained stability constants of 1 : 1 complexes are generally higher than those of the complexes of the same compounds with β-cyclodextrin (β-CD) and lower than those for dimethyl-β-CD, γ-CD, and (2-hydroxypropyl)-γ-CD complexes.

作者简介

V. Sursyakova

Institute of Chemistry and Chemical Technology, Federal Research Center “Krasnoyarsk Scientific Center,” Siberian Branch, Russian Academy of Sciences

Email: viktoria_vs@list.ru
660036, Krasnoyarsk, Russia

V. Levdansky

Institute of Chemistry and Chemical Technology, Federal Research Center “Krasnoyarsk Scientific Center,” Siberian Branch, Russian Academy of Sciences

Email: viktoria_vs@list.ru
660036, Krasnoyarsk, Russia

A. Rubaylo

Institute of Chemistry and Chemical Technology, Federal Research Center “Krasnoyarsk Scientific Center,” Siberian Branch, Russian Academy of Sciences; Siberian Federal University

编辑信件的主要联系方式.
Email: viktoria_vs@list.ru
660036, Krasnoyarsk, Russia; 660041, Krasnoyarsk, Russia

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