Preparation of a сloso-Dodecaborate Anion Conjugate with Ethyl Glycinate and Study of Its Biodistribution in a B16f10 Melanoma Model

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Abstract

A method for the synthesis of amidine-closo-dodecaborate based on glycine ethyl ester in the form of sodium salt solvate of high purity and constant composition was proposed in this work. The structure of the obtained solvate was confirmed by X-ray analysis of single crystal. In addition, total and acute toxicity as well as biodistribution in laboratory mice with B16F10 melanoma were determined for the synthesized conjugate Na[B12H11NH=C(NHCH2COOC2H5)CH3].

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About the authors

M. N. Ryabchikova

National Research University Higher School of Economics

Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 101000

A. V. Nelyubin

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 119991

A. V. Smirnova

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation

Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 115522

Y. A. Finogenova

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation

Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 115522

V. A. Skribitsky

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)

Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 115522; Moscow, 115409

K. E. Shpakova

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)

Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 115522; Moscow, 115409

A. S. Kubasov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 119991

A. P. Zhdanov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Author for correspondence.
Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 119991

A. A. Lipengolts

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)

Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 115522; Moscow, 115409

E. Yu. Grigorieva

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation

Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 115522

K. Y. Zhizhin

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 119991

N. T. Kuznetsov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 119991

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2. Fig. 1. The structure of the isopropyl complex according to the RSA data.

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3. Fig. 2. Graph of changes in boron concentration in organs and tissues after intraperitoneal conjugate administration.

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