Age-related dynamics of morphological changes in the human cortex and corpus callosum: Microgliocytes and neurofilaments as markers of aging
| Dublin Core | PKP Metadata Items | Metadata for this Document | |
| 1. | Title | Title of document | Age-related dynamics of morphological changes in the human cortex and corpus callosum: Microgliocytes and neurofilaments as markers of aging |
| 2. | Creator | Author's name, affiliation, country | Anatolii A. Balandin; Perm State Medical University named after Academician E.A. Wagner; Russian Federation |
| 2. | Creator | Author's name, affiliation, country | Lev M. Zheleznov; Kirov State Medical University; Russian Federation |
| 2. | Creator | Author's name, affiliation, country | Irina A. Balandina; Perm State Medical University named after Academician E.A. Wagner; Russian Federation |
| 2. | Creator | Author's name, affiliation, country | Vladimir A. Balandin; Perm State Medical University named after Academician E.A. Wagner; Russian Federation |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | precentral gyrus; corpus callosum; age-related features; microgliocyte; neurofilaments |
| 4. | Description | Abstract | Objectives – to analyze the number and sum of diameters of microgliocytes in the precentral gyrus cortex and the corpus callosum of a person in the early adulthood and of an old person and to identify the patterns of neurofilaments expression in these parts of the brain. Material and methods. The results of a sectional study of the cerebral cortex in the precentral gyrus and corpus callosum using hematoxylin and eosin staining were analyzed, and an immunohistochemical study was performed using antibodies to neurofilaments. The dead were divided into two groups depending on their age. The group I included 23 men and 27 women in their early adulthood, aged from 23 to 28 years; the group II included 19 men and 25 women of the old age – from 75 to 83 years. We examined the number of microgliocytes, the sum of their diameters, and the expression of neurofilament proteins in the tissue. Results. Morphometric study of autopsy material showed that in the corpus callosum, as well as in the cortex of the precentral gyrus, there was an age-related statistically significant increase in the number of microgliocytes and the sum of their diameters (p < 0.001). We found that the expression of neurofilaments in the cortex of the precentral gyrus is uniform both in the early adulthood and in old age. In the corpus callosum tissue, the age-related neurodegenerative changes are more pronounced: by old age, there is a significant decrease in the expression of neurofilaments with the formation of their rarefaction sites in the areas of microgliocyte clusters. Conclusion. The results of morphological study of the precentral gyrus cortex and corpus callosum of two age groups testify that the number and sum of diameters of microgliocytes responsible for the utilization of spent myelin have a certain relationship with age and expression of neurofilaments in the nervous tissue. |
| 5. | Publisher | Organizing agency, location | FSBEI of Higher Education SamSMU of Ministry of Health of the Russian Federation |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (DD-MM-YYYY) | 15.12.2021 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | Research Article |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://innoscience.ru/2500-1388/article/view/62659 |
| 10. | Identifier | Digital Object Identifier (DOI) | 10.35693/2500-1388-2021-6-4-4-8 |
| 10. | Identifier | Digital Object Identifier (DOI) (PDF (Rus)) | 10.35693/2500-1388-62659-69986 |
| 11. | Source | Title; vol., no. (year) | Science and Innovations in Medicine; Vol 6, No 4 (2021) |
| 12. | Language | English=en | ru |
| 13. | Relation | Supp. Files |
Figure 1. A fragment of precentral gyrus cortex of a 69-year-old man. Microgliocytes of medium and large diameters are visualized (marked with arrows). Staining with hematoxylin and eosin. 100x. (187KB) doi: 10.35693/2500-1388-62659-52084 Figure 2. A corpus callosum fragment of a 71-year-old woman. Clusters of microgliocytes of different diameters near the vessel. Staining with hematoxylin and eosin. 100x. (191KB) doi: 10.35693/2500-1388-62659-52085 Figure 3. A fragment of precentral gyrus cortex of a 79-year-old woman. Microgliocytes of small and medium diameters are visualized (marked with arrows). The expression of the neurofilament protein in the tissue is uniform, the structure itself is heterogeneous, transition zones are present. 100x. (292KB) doi: 10.35693/2500-1388-62659-52086 Figure 4. A fragment of the corpus callosum of a 72-year-old man. Clusters of microgliocytes of different diameters near the vessel. The neurofilament protein expression is reduced in the areas of microgliocytes clusters. 100x. (284KB) doi: 10.35693/2500-1388-62659-52087 |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright (c) 2021 Balandin A.A., Zheleznov L.M., Balandina I.A., Balandin V.A. This work is licensed under a Creative Commons Attribution 4.0 International License. |