Science and Innovations in Medicine

Peer-reviewed journal of medical research and practice founded in 2016.

Founder and Publisher

Samara State Medical University
WEB: https://en.samsmu.ru/ 

Editor-in-chief

Aleksandr Kolsanov, MD, Doctor of Medical Sciences, Professor of the Russian Academy of Sciences, Professor
ORCID iD: 0000-0002-4144-7090


 

About

Journal Audience

The journal is intended for researchers, medical practitioners, medical professionals including those involved in allied fields of medicine, as well as students and postgraduates of medical universities.

Mission of the Journal

Mission of the Journal:

  • to enhance the expertise of medical professionals;
  • to promote the advancement of the medical community’s scientific potential;
  • to encourage medical practitioners to develop clinical thinking.

Objectives of the Journal

  • to provide authoritative coverage of current achievements in medical science;
  • to introduce readers to the results of current Russian and foreign clinical and experimental studies;
  • to integrate the results of Russian scientific research into the international scientific context;
  • to highlight the most promising areas of medical science development;
  • to assist physicians in mastering advanced technologies in the area of diagnostics, treatment, and prevention of a wide range of diseases;
  • to promote the efficient incorporation of scientific research results into health care practices.
Types of Publications
  • Original Study Articles
  • Systematic Reviews
  • Meta-analisys
  • Reviews
  • Clinical case reports and cae series
  • Short communications
  • Editorials

The editorial board reserves the right to compile thematic issues for the journal.

Journal Language

The journal invites manuscripts in Russian and/or English. Accepted articles publish:

  • with metadata in both Russian and English;
  • with full-text in Russian and/or English (depending on the language of the manuscript and the authors' wishes).
Authors, Reviewers and Editorial Board

Scientists and physicians contribute in designing the content of the journal through their manuscripts. All materials published in the journal are subject to thorough double-blined peer-review.

The publication of articles is free of charge for all authors of the journal (no APC, no ASC).

The decision to publish each article is based on the opinion of independent peer-reviewers and an assessment of its compliance with the established ethical requirements.

The international editorial board of the journal comprises of well-known Russian specialists, including full members of the Russian Academy of Sciences, as well as reputable scientists from Belarus, Germany, Denmark, Israel, Kazakhstan, USA, Uzbekistan, and France.

Publication Frequency and Distribution of the Journal

The journal is issued four times a year (quarterly) and is distributed in printed and electronic format (on the Internet).

  • all articles are available online immediately after publication under the terms of open access (Platinum Open Access) with the CC BY Attribution 4.0. license.
  • Print subscription is available through the catalog of the “Russian Post” agency. The journal is also distributed at specialized medical forums and exhibitions.
Indexing
  • Russian Science Citation Index (eLibrary.ru)
  • DOAJ
  • Cyberleninka
  • Google Scholar
  • Ulrich’s Periodicals Directory
  • Dimensions
  • Crossref

The journal is registered with the Federal Service for the Supervision of Communications, Information Technology, and Mass Media (Russian Federation). The Mass Media registration certificate ПИ No. ФС77-65957 was issued on June 06, 2016.

 


Announcements More Announcements...

 

“Science and Innovations in Medicine” is included in the DOAJ

Posted: 26.09.2024

Dear Colleagues!

It is our pleasure to inform you that following an expert assessment the journal “Science and Innovations in Medicine” is included in one of the high-ranking international databases of scientific information, the DOAJ (Directory of Open Access Journals).

Journal page: https://doaj.org/toc/2618-754 

DOAJ's mission is to increase the visibility, accessibility, reputation, usage and impact of quality, peer-reviewed, open access scholarly research journals globally, regardless of discipline, geography or language.

DOAJ has very stringent criteria of selection of journals and thorough review of data submitted for perusal. Our inclusion in the database is a confirmation that the journal meets the requirements of a world-class publication


 

Current Issue

Vol 10, No 2 (2025)

Cover Page

Full Issue

Human Anatomy

Anatomy of the ileum-intestinal tract of the human fetus at 16–22 weeks of ontogenesis
Vasileva T.A., Galeeva E.N., Galiakbarova V.A., Grigoreva A.A.
Abstract

Aim – to obtain new data on the quantitative macromicroscopic anatomy of the iliac-intestinal region in the intermediate fetal period of human ontogenesis from the 16th to the 22nd week of development.

Material and methods. The study was performed on 30 subjects of both sexes (18 female and 12 male fetuses) using the following methods: macro- and microscopic preparation, N.I. Pirogov sawing, histotopographic method, morphometry, and variation-statistical methods. All the morphometric data obtained were subjected to variation-statistical processing in Windows XP-based Excel 2010 and Statistics 13.0 application software packages. When testing statistical hypotheses in this study, the critical level of statistical significance (p) was assumed to be 0.05. The Student’s t-test was used to assess the reliability. A set of tools for macromicroscopic preparation of the fetus was used.

Results. During the period of development in question, the position of the ileum has slight vertical deviations, which affects the formation and magnitude of the angle between the ileum and the cecum, as well as between the ileum and the ascending colon. The predominant shape of the cecum is cylindrical (80%), less often conical (20%). There is an uneven growth of the walls of the cecum, where the lateral wall prevails over the medial one, which is associated with the formation of flap structures. The ileo-intestinal opening is oval in shape, the frenules are weakly pronounced, with a more pronounced ileo-colon lip. Semilunar folds are differentiated on the mucous membrane of the cecum from 16-17 weeks, and a free muscle band is also determined. The omental and mesenteric bands are not pronounced. There is no morphological boundary between the appendix and the cecum. From 19-20 weeks, the presence of 1-2 gausters is noted. The quantitative parameters of the iliac-intestinal region are characterized by a gradual twofold increase in values.

Science and Innovations in Medicine. 2025;10(2):84-91
pages 84-91 views

Pathological anatomy

Role of membrane components in the initiation and progression of tumour growth in endometrial cancer
Atadzhanov I.B., Guskova O.N., Shestakova V.G.
Abstract

This review discusses the role of membrane components in the initiation and progression of endometrial cancer. Cancer cells that are the substrate of the tumor growth are subject to multiple interactions both among themselves and with the tumor microenvironment.The cell membrane of tumor cells undergoes changes, resulting in simplified antigenic structure and the expression of molecules found in embryonic tissues, changes in the intercellular contacts that maintain epithelial homeostasis. Dense contacts form the basis for the preservation of normal endometrial histological organization. These changes also affect intercellular contacts, leading to the alteration of mechanical properties and invasive growth of tumor cells. In addition, components of dense contacts are participants of intracellular signal transduction pathways. The review highlights the potential role of claudin proteins, specifically in tight junctions and intracellular signaling, as promising targets for further study. Epithelial-mesenchymal transformation (EMT) represented in normal tissues in processes of reparation, plays a significant role in endometrial cancer progression, and the altered characterization of E-cadherin and β-catenin is important in understanding EMT’s role in the disease. Researchers are focusing on the E-cadherin as a component of oncogene activation pathways. Hyperestrogenemia (high serum estrogen levels) is known to underlie Type I endometrial adenocarcinoma. Additionally, estrogen receptors and claudins are implicated in intracellular signaling activating cell proliferation both in the norm and in the course of disease. Recent research also involved other molecules serving as targets for estrogens, e.g. claudin proteins. Change of clausin expression profiles mediated by sex hormones manifest both in suppression and replacement of one protein with another. Further study of cell membrane-associated markers has the potential to provide insights into tumor biology and aid in the development of new therapeutic approaches for endometrial cancer.

Science and Innovations in Medicine. 2025;10(2):92-99
pages 92-99 views
Microscopic features of chronic cheilitis
Lebedev S.N., Solnyshkina A.F., Guskova O.N., Lebedeva Y.V., Marku D.V., Skaryakina O.N., Lebedev I.S.
Abstract

Aim – to evaluate morphological changes of the lip mucosa in chronic cheilitis: the condition of the epithelium, the microcirculation and the inflammatory infiltration of the intrinsic lamina of the mucosa.

Material and methods. A retrospective analysis was performed of medical records, biopsy specimens and archive histological material after lip resection in patients with the diagnosis of chronic cheilitis (Tver Regional Clinical Oncological Dispensary). The sample consisted of 46 patients aged 34–72 years (19 women and 27 men). After the microscopic examination, two groups have been formed: Group A, instances of chronic inflammation of the lip without signs of epithelial dysplasia (n=24), Group B, instances with low- and high-grade dysplasia in the squamous epithelium (n=22). Changes in the epithelium, severity of hyperplasia, stratification, degree of epithelial cells maturation, karyopycnotic index, and character of inflammatory infiltrate and vascularization of intrinsic lamina of the mucosa were evaluated. Microscopic examination was performed using an Olympus CX-41 light microscope with a digital camera. Specialized software suite Video Test-Morphology 5.2 was used to study 10 fields of view of the microscope (×40 lens magnification, ×10 eyepiece) in every specimen: diameter, number of blood vessels and stromal and angiomatous components ratio measured per 1 mm2. The data was statistically processed using SPSS 22.0 suite.

Results. Elderly men predominated in both groups. A comparative analysis of changes in the squamous epithelium, inflammatory reaction, and the nature of vascularization of the proper mucosa plate was performed. According to the results of morphometry, it was found that in patients of Group B the number of vessels per unit area was significantly higher than in Group A. Microscopic features of reactive changes in the epithelium and proper plate of the mucous membrane of the red border of the lips predisposing to malignant transformation were found. In chronic cheilitis with epithelial dysplasia, an uneven arrangement of vascular loops with alternating sections of hypovascularized stroma and foci of increased vascularization of the proper mucosa plate due to the accumulation of small capillaries was noted, which can be recommended as a morphological sign of an unfavorable prognosis of the inflammatory process of the red lip rim.

Conclusion. In the differential diagnosis of lip diseases, pathologists should note the nature and severity of microcirculatory changes and inflammatory infiltration in the mucous membrane at the conclusion of the pathology study, along with the characteristics of squamous epithelium dysplasia, and clinicians should consider these morphological data when choosing treatment tactics for patients.

Science and Innovations in Medicine. 2025;10(2):100-106
pages 100-106 views

Cardiology

Multifactorial prediction of adverse outcome of acute coronary syndrome combined with post-COVID syndrome
Kozik V.A., Shpagina L.A., Shpagin I.S.
Abstract

Aim – to build a multivariate model for predicting adverse outcomes of acute coronary syndrome with and without ST segment elevation in patients with post-COVID syndrome.

Material and methods. The study included 118 patients (61 men and 57 women) with acute coronary syndrome and post-COVID syndrome. All patients underwent medical history review, clinical examination, laboratory tests, coronary angiography, echocardiography, electrocardiography, and molecular genetic marker testing. The influence of each factor on the probability of developing a combined endpoint, including the total number of cardiovascular complications and fatal outcomes, was assessed using logistic regression analysis. The statistical significance of the model was determined by the χ² test. The sensitivity and specificity of the model were assessed using ROC analysis.

Results. The constructed multivariate regression model showed that the development of an unfavorable outcome in patients with acute coronary syndrome in combination with PCS is associated with the presence of chronic heart failure, elevated soluble fms-like tyrosine kinase-1, hypokinesis zones on echocardiography, carrier status of the TT/AA genotype of the genetic marker rs2285666 of the ACE2 gene (χ² = 38.416, p <0.001). The sensitivity of the model is 93.5%, and the specificity is 21.8%, the accuracy is 76.6%, the area under the curve (AUC) = 0.8.

Conclusion. A multivariate regression model was constructed and tested to predict, with high accuracy, the development of an unfavorable outcome of acute coronary syndrome in combination with post-COVID syndrome.

Science and Innovations in Medicine. 2025;10(2):107-111
pages 107-111 views
An increase of the left atrium sphericity index can serve as a marker of paroxysmal atrial fibrillation in patients with hypertension
Mazur V.V., Nilova O.V., Nikolaeva T.O., Bazhenov N.D., Mazur E.S.
Abstract

Aim – to study the possibility of using the left atrium sphericity index (SI), calculated by echocardiography (EchoCG), to identify patients with hypertension with paroxysmal atrial fibrillation (AF).

Material and methods. The study included 298 patients with hypertension, of whom 77 (25.8%) showed paroxysmal AF during 24-hour electrocardiogram monitoring. The control group included 58 patients without cardiovascular diseases. The left atrium volume was determined and the maximum left atrium length was measured. The SI was calculated as the ratio of the left atrium volume to the volume of a sphere whose diameter is equal to the maximum left atrium length.

Results. The average values of SI (presented as the median and 95% confidence interval) increased from the control group to the group of patients with hypertension without AF and to the group of patients with hypertension and AF: 0.68 (0.64–0.72), 0.71 (0.69–0.72) and 0.92 (0.91–0.94), p <0.0001. Multiple linear regression analysis showed that 1-year increase of the age is associated with increase in SI by 0.0015 units, the presence of obesity is accompanied by an increase of SI by 0.0241 units, and the presence of paroxysmal AF leads to an increase in SI by 0.2031 units. All patients included in the study were randomly divided into derivation and validation cohorts (238 and 118 patients). In the derivation cohort, the AUC for SI, as a predictor of AF, was 0.955 (0.920–0.977), and cut-off point was 0.82. In the validation cohort, the ‘SI>0.82’ criterion, a sign of AF, demonstrated sensitivity of 100 (86.8–100.0) % and specificity of 93.5 (86.3–97.6) %.

Conclusion. The SI calculated by EchoCG has a high discriminating ability in relation to paroxysmal AF in patients with hypertension.

Science and Innovations in Medicine. 2025;10(2):112-118
pages 112-118 views
Prediction of adverse outcomes in the long-term follow-up period in patients with chronic heart failure who have suffered a myocardial infarction
Trusov Y.А., Shchukin Y.V., Limareva L.V.
Abstract

Aim – to determine the prognostic significance of global longitudinal strain of the left ventricle (GLS) and soluble stimulating growth factor (sST2) in patients with chronic heart failure (CHF) after myocardial infarction (MI) in the annual follow-up period.

Material and methods. The study included 96 patients with CHF who were hospitalized with acute MI. All subjects underwent speckle-tracking echocardiography and determination of concentrations of sST2, vascular endothelial growth factor (VEGF), N-terminal pro-brain natriuretic peptide (NT-proBNP) and C-reactive protein (CRP). After 12 months patients were assessed for cases of stroke, recurrent myocardial infarction, hospitalization for unstable angina or decompensation of CHF, and cardiovascular death, forming a combined endpoint (CEP).

Results. The development of CEP was registered in 44 (45.8%) patients with initially lower left ventricular ejection fraction and GLS, higher left ventricular myocardial mass index, index of impaired local contractility, basal diameter of the excretory tract, as well as a higher score on the Syntax scale and concentrations of CRP, NT-proBNP and sST2. During the ROC-analysis for the development of CEP, optimal thresholds for sST2 and NT proBNP were determined, which were 36.1 ng/ml and 427 pg/ml, respectively. The multifactorial analysis made it possible to develop a mathematical model for predicting adverse outcomes within 12 months after MI, which included such indicators as GLS – odds ratio (OR) 0.51 (0.39; 0.72), the number of points on the Syntax scale – OR 3.05 (2.2; 6.8), concentrations of NTproBNP – OR 2.9 (1.45; 5.1) and sST2 – OR 3.3 (1.65; 7.51).

Conclusion. The developed prognostic model includes factors reflecting various links in the pathogenesis of CHF, which provides an integrated approach to assessing the risks of recurrent cardiovascular events after MI.

Science and Innovations in Medicine. 2025;10(2):119-127
pages 119-127 views

Oncology and radiotherapy

Role of mini-invasive technologies in the treatment of colon cancer in the aged patient population
Galkin V.N., Erygin D.V., Orozbekov A.O., Sklyar I.А., Abibillaev D.A., Konurbaev B.T., Baktybek A.
Abstract

Aim – to evaluate the effectiveness of surgical treatment for colorectal cancer in patients aged 75–90 years (WHO, 2002) in the early postoperative period after laparoscopic and open surgeries. The primary outcome was the total length of hospital stay (bed-days). Secondary outcomes included intraoperative blood loss, C-reactive protein (CRP) levels, postoperative pain (VAS), and the incidence of general and surgical complications.

Material and methods. The study included colorectal cancer (CRC) patients (75–90 years old) who underwent laparoscopic (LS) or laparotomic (LT) surgery. A comparative analysis of demographic, clinical-laboratory, and surgical data was performed.

Results. The LS group demonstrated a shorter hospital stay (10 (3) vs. 10 (7) days, p≤0.001) and lower intraoperative blood loss (50 (20) vs. 150 (150) ml, p≤0.001) compared to the LT group. The LT group had significantly higher CRP levels on days 3 and 5 (p≤0.001) and a higher incidence of complications (pneumonia, anemia, acute urinary retention), 18 (33.9%) vs. 6 (7.2%), p≤0.001. Operative time (p=0.002) and postoperative complications significantly influenced hospital stay duration.

Conclusion. Laparoscopic surgery results in a shorter hospital stay, reduced intraoperative blood loss, lower inflammatory response, and decreased postoperative pain and complication rates. These advantages make it the preferred method for treating elderly patients with colorectal cancer, especially in the presence of comorbidities.

Science and Innovations in Medicine. 2025;10(2):128-135
pages 128-135 views
Retrospective analysis of surgical outcomes of delayed pharyngeal defect reconstruction in patients with advanced laryngeal and laryngopharyngeal cancer after laryngectomy
Kaganov O.I., Sidorenko A.O., Orlov A.E., Makhonin A.A., Gabrielyan A.G.
Abstract

Aim – to retrospectively analyze the results of surgical treatment of delayed reconstruction of pharyngeal defects in patients with advanced laryngeal and laryngopharyngeal cancer after laryngectomy.

Material and methods. We performed a retrospective analysis of 437 case histories of patients treated in Samara Regional Clinical Oncology Center in the period from 2015 to 2019 with malignant neoplasms of the larynx and laryngeal pharynx, who had previously undergone combined and extended-combined laryngectomies. In the retrospective analysis, we studied the structure of complications after delayed reconstructive surgeries of type 0-II pharyngeal and pharyngo-esophageal defects. Local tissue, pectoral flap, and deltopectoral flap were used as plastic material. Complications in the postoperative period were observed in all types of plasty.

Results. The most frequent complications included inflammation of the postoperative wound, anastomosis failure with subsequent formation of fistulas or secondary faryngostomas. In type 0 pharyngeal defects, plastic surgery with the use of local tissues showed a good result, postoperative complications occurred in 11% of cases. In I type pharyngeal defects, fistulas and secondary stomas in the postoperative period were formed in 83% of cases when local tissues were used, in 45.8% when pectoral flap was used and in 66.5% when deltopectoral flap was used. In type II of the defect, the percentage of postoperative complications when using a pectoral flap was 75% and deltopectoral flap – 100%.

Conclusion. Complications in the postoperative period were observed in all types of plasty. The study of risk factors and creation of the algorithm for selection of patients for delayed plasty will allow to determine the terms and indications for delayed reconstructive-reconstructive surgery, as well as to reasonably reduce the risk of postoperative complications.

Science and Innovations in Medicine. 2025;10(2):136-141
pages 136-141 views
Comparative safety of intracorporeal versus extracorporeal anastomoses in laparoscopic right colectomy
Salamakhin M.P., Leonov O.V., Milovanova A.Z., Mamedli Z.Z.
Abstract

Aim – to assess the safety of a hand-sewn intracorporeal ileo-transverse anastomosis.

Material and methods. The retrospective study included patients from the Omsk Regional Cancer Registry from 2015 to 2023. It included patients with colon cancer (ICD-10 C18), who underwent a laparoscopic right colectomy. In the study group patients had hand-sewn intracorporeal anastomoses dene under an original method, terminus-terminal invagination ileo-transverse anastomosis; in the control group patients had hand-sewn ‘side-to-side’ extracorporeal anastomoses.

Results. 89 patients were enrolled: 42 in the study group and 47 in the control group. No cases of anastomotic leakage were found in the study group versus 2 (4.3%) in the control group (p=0.496). Grade 3 and higher surgical morbidity was equal in both groups: 2 (4.8%) versus 5 (10.7%), p=0.550.

Conclusion. The hand-sewn original intracorporeal anastomosis is safe and can be considered by experienced laparoscopic surgeons. Further study is needed for a detailed comparative analysis with established techniques.

Science and Innovations in Medicine. 2025;10(2):142-146
pages 142-146 views

Traumatology and Orthopedics

Development and risk factors of chronic pain due to trauma to the anterior cruciate ligament and/or meniscus of the knee joint
Byalik A.A., Karateev A.E., Makarov S.A., Byalik Е.I., Byalik V.Е., Nesterenko V.A., Kudinsky D.M.
Abstract

Aim – to evaluate the incidence and risk factors of chronic post-traumatic pain in patients who suffered an anterior cruciate ligament (ACL) and/or knee joint meniscus (CC) injury.

Material and methods. The study group consisted of 148 patients (48.0% women, 37.9 ± 13.1 years old) who had suffered an injury to the PC and/or meniscus of the CS, confirmed by magnetic resonance imaging (MRI). The inclusion criterion was moderate/severe pain (≥4 on the numerical rating scale, NRS 0-10) 1 month after the injury. Patients were examined after 3, 6, and 12 months with an assessment of pain (NRS) and the KOOS index, signs of neuropathic pain (painDETECT), anxiety and depression (HADS a and HADS d), central sensitization index (CSI), pain catastrophization (PCS), fibromyalgia symptoms (FiRST), fatigue (FACIT). An MRI scan was performed after 6 and 12 months. The plasma concentrations of a number of biomarkers (HCRP, NTX, ADAMTS-5, COMP, MMP3, MMP9, MMP13, substance P) were studied.

Results. After 3 months, pain with movement ≥4 NRS was observed in 58 (39.2%) patients. These patients formed the group with chronic post-traumatic pain (CPTP+), patients with lower pain intensity or absence (≤4 NRS) formed the control group (CPTP-). In patients with CPTP+, compared with the CPTP- group, pain at rest and at night was significantly higher (p <0.001). A significant difference in pain during movement, at rest, and at night, as well as all KOOS scales, remained between the CPTP+ and CPTP- groups after 6 and 12 months. In the CPTP+ group, there was a tendency to a higher frequency of signs of neuropathic pain, anxiety and depression, central sensitization index, pain catastrophization scale and fatigue, however, the difference with the CPTP- group was unreliable. The concentration of biomarkers in the CPTP+ and CPTP- groups did not differ. There was a significant association between CPTP and the female sex (odds ratio = 3.18; 95% confidence interval 1.606-6.297, p<0.001), meniscus injury (OR = 2.132; 95% CI 1.07-4.252, p=0.03), osteitis (OR = 5.734; 95% CI 2.106-15.609, p<0.001) and synovitis (OR = 2.35; 95% CI 1.186-4.656, p=0.013) according to MRI, surgery (reduced the risk of CPTP, OR = 0.385; 95% CI 0.195-0.759, p<0.005), initially severe pain (≥7 NRS, OR = 5.553; 95% CI 1.696-18.179, p=0.002), signs of highly probable CS (CSI ≥40, OR = 3.915; 95% CI 1.147-13.368, p=0.021) and severe depression (HADS ≥ 11, OR = 4.12; 95% CI 1.672-21.983, p=0.05).

Conclusion. CPTP occurs in almost 40% of patients after knee joint meniscus injury. Risk factors for CPTP are female gender, meniscus injury, osteitis and synovitis (MRI data), initially severe pain, central sensitization, and depression.

Science and Innovations in Medicine. 2025;10(2):147-154
pages 147-154 views
Kinematic analysis of gait in children with rigid flatfoot before and after surgical treatment
Khodjanov I.Y., Umarov X.I., Khakimov S.K., Mirzaev A.G.
Abstract

Aim – to study the kinematics and kinetics of walking in children with rigid flatfoot by comparing data before and after surgical operations.

Material and methods. The study included 51 patients (42 boys, 9 girls) with rigid flatfoot, with a mean age of 10.5 ± 1.4 years. They were stratified by disease stage and underwent surgical treatment using the author’s technique: ‘transposition of the m. peroneus longus tendon medially, shortening of the m. tibialis posterior tendon, and arthrodesis of the cuneo-navicular joint’.

Results. It was found that higher disease stages correlated with increased step time and support time, and decreased swing time, average walking speed, and step frequency (<0.01 to <0.001). Disease progression also exacerbated pathomorphological changes in the foot, driven by biomechanical dysfunction of the lower leg’s pronator and supinator muscles, alongside reduced gait energy efficiency.

Conclusion. Gait kinematic assessment, when combined with standard diagnostic tools for rigid flatfoot (e.g., radiography and podometry), enhances the identification of effective and precise treatment strategies. The proposed disease stage-adjusted corrective approach addresses all components of rigid flatfoot: it eliminates pathological pronation, restores supination and plantar flexion function, and achieves adequate foot arch reconstruction.

Science and Innovations in Medicine. 2025;10(2):155-160
pages 155-160 views

Surgery

Comparative analysis of accuracy and time of calculation of wound surface area using mobile applications
Mikhailov N.O., Glukhov A.A., Andreev A.A., Laptieva A.Y., Sudakov O.V., Ivashkov V.Y., Denisenko A.S.
Abstract

Aim – to carry out a comparative assessment of the accuracy and time of calculating the area of the wound surface using mobile applications.

Material and methods. Wound areas were measured using mobile applications +WoundDesk, ImitoWound and V2F in four blocks of the study: schematic 2D image of soft tissue wounds (block I), volumetric (3D) models of wounds in fractures of the shoulder and leg (block II), experimental wounds in laboratory animals (block III) and assessment of combined wound defects upper and lower jaws in patients (IV block). In the first block, four groups were identified: the 1st group was measured by the area of schematic wounds on a flat surface; in the 2nd, 3rd and 4th groups, by the area of schematic wounds painted on cylindrical surfaces with a diameter of 7, 10 and 20 cm, imitating the surfaces of the forearm, shoulder and head, respectively.

Results. In block I, there is a direct relationship between the curvature of the examined wound surface and the accuracy of determining its area. In the second block, the measurements obtained using the ImitoWound mobile application turned out to be the most accurate, 96.22±3.41% and 97.80±2.37%. In the III block of the study conducted on laboratory rats of the Wistar line, the average deviation when using +WoundDesk was 90.84±7.51%, V2F – 88.96±9.52%, ImitoWound – 92.51±2.54%. In the IV block of the study, when analyzing the accuracy of determining the area of defects of superficial soft tissues in patients with facial defects, the ImitoWound mobile application and the Autoplan complex showed similar results.

Conclusion. Most wounds encountered in medical practice have a complex configuration that changes during treatment, changing from one form to another, which calls into question the expediency of using the presented mobile applications as the main method of conducting planimetric studies in medicine.

Science and Innovations in Medicine. 2025;10(2):161-168
pages 161-168 views
Analysis of clinical effectiveness of complex treatment of limited border burns
Tolstov A.V., Kolsanov A.V., Novikov I.V., Milyudin E.S.
Abstract

Aim – to evaluate the effectiveness of the developed method for local treatment of limited border burns.

Material and methods. The results of treatment of 39 patients with limited first- and second-degree burns were studied. In patients of the main group (19 people), during the changing of the gel with silver ions, the wound was irradiated with ultraviolet light, followed by exposure to a low-frequency pulsating magnetic field. Patients in the comparison group (20 patients) received conservative treatment using the gel with silver ions only, without physiotherapy. Monitoring of the healing of burn wounds was carried out using the “Complex automated system for assessing the area of burn wounds” (certificate of state registration of the computer program No. 2015660700 dated 10/06/2015). The effectiveness of the proposed method was assessed by clinical results, as well as by the time patients spent in the hospital. The obtained data were analyzed using clinical statistics methods.

Results. The developed method for treating local I-II degree burn wounds, which consists of covering the wound with gel with silver plus ultraviolet irradiation of the wound and magnetic therapy, turned out to be more effective compared to the method of wound coating with gel with silver, which was previously introduced into the clinic, without physiotherapeutic treatment.

Conclusions. The use of the proposed method in the treatment of burn wounds statistically significantly reduces the likelihood of the development of suppuration and accelerates the cleansing of wounds, and leads to a faster recovery.

Science and Innovations in Medicine. 2025;10(2):169-174
pages 169-174 views